Catalog No.
Product Name
Application
Product Information
Citations
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Prolyl Endopeptidase Inhibitor
SUAM 1221 is a potent inhibitor of prolyl endopeptidase, an enzyme involved in the metabolism of neuroactive peptides. This compound exhibits significant biological activity by modulating peptide levels, making it a valuable tool in Alzheimer’s disease research. Its application facilitates the exploration of therapeutic strategies aimed at neurodegeneration and cognitive decline. -
Prolyl Endopeptidase (PEP) Substrate
Suc-Ala-Pro-pNA is a specific substrate for prolyl endopeptidase (PEP), designed to facilitate the measurement of PEP activity and stability. This peptide substrate releases para-nitroaniline (pNA) upon hydrolysis, enabling quantification in various experimental settings. It is valuable for biochemical assays and research focused on proteolytic enzyme activity, particularly in the context of neurodegenerative diseases and other related disorders. -
PREP Inhibitor
PREP inhibitor-1 is a potent prolyl oligopeptidase (PREP) inhibitor with an IC50 value of less than 1 nM. This compound selectively targets PREP, an enzyme involved in the modulation of neuropeptides and signaling pathways. Its high inhibitory activity makes it a valuable tool for research on neurodegenerative disorders and related neurological studies. -
Prolyl Endopeptidase (PREP)
Z-Gly-Pro-pNA is a substrate designed for the assessment of prolyl endopeptidase (PEP) activity. This compound can be utilized in assays to quantify PEP inhibition, offering insights into enzymatic function and regulation. It serves as an important tool for researchers investigating the role of PEP in various biological processes and potential therapeutic targets. -
Prolyl endopeptidase Inhibitor
Prolyl Endopeptidase Inhibitor 1 is a potent inhibitor of prolyl endopeptidase (PEP), with a Ki value of 15 nM. Its inhibitory action on PEP suggests potential applications in neurobiology, particularly for the investigation of cognitive processes. Additionally, Prolyl Endopeptidase Inhibitor 1 has demonstrated anti-amnesic effects, indicating its relevance in research on memory and cognitive disorders. -
Prolyl endopeptidase Inhibitor
Prolyl Endopeptidase Inhibitor 2 is a selective inhibitor of prolyl endopeptidase (PEP) with an IC50 value of 31.11 μM. This compound plays a crucial role in the modulation of proline-rich peptides and is relevant to research on neurodegenerative diseases. Its ability to inhibit PEP makes it a valuable tool for exploring therapeutic strategies in conditions where peptide degradation is implicated. -
PREP Inhibitor
Pramiracetam sulfate is a selective inhibitor of prolyl endopeptidase (PREP). It has been shown to enhance cognitive function, particularly following traumatic brain injury, making it a valuable tool in studying neurodegenerative diseases. This compound is suitable for research focused on the mechanisms of cognitive enhancement and potential therapeutic interventions for brain injuries and related disorders. -
POP Inhibitor
POP-IN-2 is a potent, covalent inhibitor of prolyl oligopeptidase (POP) with a Ki value of 6 nM. This reagent serves as a valuable tool for investigating the physiological roles of POP in neurodegenerative diseases and cancer, facilitating research into therapeutic strategies targeting these conditions. Its high specificity makes it suitable for detailed mechanistic studies in various biological contexts. -
PREP Inhibitor
Y-29794 is a selective, orally active inhibitor of non-peptide prolyl endopeptidase (PREP), demonstrating an IC50 of 3 nM and a Ki of 0.95 nM. It enhances the efficacy of thyrotropin-releasing hormone (TRH) on acetylcholine release in the rat hippocampus, indicating potential neuroprotective effects. Additionally, Y-29794 exhibits anticancer activity by inhibiting the IRS1-AKT-mTORC1 signaling pathway and shows the capability to penetrate the blood-brain barrier (BBB), making it valuable for various neurological and oncology research applications. -
Prolyl Endopeptidase Inhibitor
Z-Thioprolyl-Thiazolidine is a potent and selective inhibitor of prolyl endopeptidase, exhibiting a Ki value of 0.36 nM for bovine brain prolyl endopeptidase. This compound is valuable for research applications focused on peptide metabolism and neuropeptide regulation. Its specificity makes it an essential tool for studying the physiological and pathological roles of prolyl endopeptidase in various biological systems. -
POP Inhibitor
POP-IN-1 is a potent inhibitor of prolyl oligopeptidase (POP), exhibiting a Ki value of 0.009 μM. This compound demonstrates significant inhibitory activity, making it valuable for research related to neurodegenerative diseases and cancer progression. Its ability to modulate POP activity provides a valuable tool for investigating therapeutic strategies in these critical areas of study. -
Prolyl Endopeptidase (PREP) Inhibitor
Z-Pro-Pro-aldehyde-dimethyl acetal is a highly selective inhibitor of prolyl endopeptidase (PREP), a serine endoprotease located in the cytoplasm, with an IC50 value of 12 nM. This compound is vital for investigating cognitive dysfunction associated with aging and neurodegenerative diseases such as Alzheimer's disease. Its ability to modulate PREP activity makes it a valuable tool for research in neurobiology and related therapeutic areas. -
PREP Inhibitor
Linderene acetate is a prolyl endopeptidase (PREP) inhibitor derived from the root of Lindera strychnifolia. This compound exhibits significant biological activity in modulating peptide metabolism and has potential applications in neurodegenerative research, where PREP plays a role in the regulation of neuropeptides. Its inhibition may offer insights into therapeutic strategies for disorders related to dysregulated peptide processing. -
Prolyl Endopeptidase (PREP)
Ala-Ala-βNA is a dipeptidyl-fluoronaphthylamide (βNA) that primarily targets prolyl endopeptidase (PREP). This compound undergoes efficient hydrolysis, demonstrating optimal activity at a pH range of 8.5 to 9.0. Ala-Ala-βNA is valuable for studying the enzymatic mechanisms of PREP and assessing its role in various biological processes, making it an essential reagent for biochemical research applications. -
PREP Inhibitor
ARI-3531 is a selective inhibitor of prolyl oligopeptidase (PREP), exhibiting a Ki of 0.73 nM. This compound is valuable for investigating the mechanisms underlying tumor invasion and metastasis, enabling enhanced understanding of cancer progression and potential therapeutic interventions. -
Prolyl Endopeptidase Inhibitor
Z-Thioprolyl-Thioproline is a selective inhibitor of prolyl endopeptidase (PEP), exhibiting an IC50 of 16 µM and a Ki of 37 µM. This compound is utilized in research focused on neurological disorders, particularly pertaining to memory and cognitive impairments. Its ability to modulate PEP activity makes it a valuable tool for investigating potential therapeutic strategies for these conditions. -
POP Inhibitor
POP-IN-3 is a potent, covalent inhibitor of prolyl oligopeptidase (POP), exhibiting a Ki of 0.95 nM. This compound is valuable for research into neurodegenerative diseases and cancer, as it modulates the activity of POP, an enzyme implicated in cellular signaling and disease progression. It is suitable for in vitro and in vivo studies to explore the therapeutic potential of targeting POP in various pathological conditions. -
PREP Inhibitor
JTP-4819 is a highly selective inhibitor of prolyl endopeptidase (PREP), exhibiting potent inhibition with IC50 values of 0.83 nM in rat brain supernatant and 5.43 nM in Flavobacterium meningosepticum. This compound demonstrates significant blood-brain barrier penetration, making it relevant for neuropharmacological studies. JTP-4819 has shown promise in enhancing memory retention in amnesia models induced by scopolamine, supporting its applications in cognitive research and potential therapeutic development for memory disorders. -
PREP Inhibitor
Z-Pro-prolinal is a potent inhibitor of prolyl endopeptidase (PREP), exhibiting an IC50 value of 0.4 nM for porcine PREP. This compound is characterized by its oral bioavailability and specificity, making it a valuable tool for investigating PREP's role in physiological processes. Research applications include studying neuropeptide metabolism and potential therapeutic interventions in neurodegenerative diseases. -
Prolyl Endopeptidase Inhibitor
Poststatin is a selective inhibitor of prolyl endopeptidase (PEP), a key enzyme involved in the degradation of bioactive peptides such as bradykinin. By inhibiting PEP, Poststatin enhances the levels of bradykinin, which may play a crucial role in modulating pain and inflammation. This reagent is valuable for research applications focused on pain pathways, inflammatory responses, and cardiovascular regulation. -
Prolyl Endopeptidase Inhibitor
Kynapcin-13 is a non-competitive inhibitor of prolyl endopeptidase (PEP), exhibiting an IC50 of 76.80 μM. It selectively targets PEP with minimal inhibition of other serine proteases. This compound is valuable for research applications investigating the role of PEP in various physiological processes and its implications in neurodegenerative diseases. -
Prolyl Endopeptidase Inhibitor
Polyozellin is a potent prolyl endopeptidase inhibitor known for its capacity to modulate proteolytic activity. This compound demonstrates significant anti-inflammatory, anticancer, and antioxidant properties, making it a valuable tool in the study of various disease mechanisms. Its application extends to research on inflammation, cancer therapy, and the management of oxidative stress-related disorders. -
Prolyl Endopeptidase Inhibitor
Kynapcin-28 is a non-competitive inhibitor of prolyl endopeptidase (PEP), demonstrating an IC50 value of 76.80 μM. This compound selectively inhibits PEP while exhibiting minimal effects on other serine proteases. Kynapcin-28 is valuable for studying protein metabolism and has potential applications in neurodegenerative disease research, where PEP modulation may play a critical role. -
Prolyl Endopeptidase Inhibitor
Eurystatin A is a selective inhibitor of prolyl endopeptidase, an enzyme involved in the cleavage of proline-containing peptides. This compound exhibits significant biological activity by modulating peptide metabolism, which has implications in various physiological processes. Research applications include studying the role of prolyl endopeptidase in neurodegenerative diseases and exploring its potential therapeutic effects in related disorders. -
PED Inhibitor
Eurystatin B is an inhibitor of prolyl endopeptidase (PED), a crucial enzyme involved in peptide metabolism. It demonstrates protective effects against memory impairment induced by scopolamine in rodent models, indicating potential applications in cognitive research and neuroprotection studies. This compound may be valuable for investigating mechanisms underlying memory disorders and developing therapeutic strategies.
