Y-33075 hydrochloride

Catalog No.: A36828
ROCK Inhibitor
Y-33075 hydrochloride is a selective inhibitor of the Rho-associated protein kinase (ROCK). It exhibits enhanced potency compared to its predecessor, Y-27632, with an IC50 of 3.6 nM. This compound is utilized in research to elucidate the role of ROCK in various biological processes, including cellular motility, proliferation, and apoptosis. Its application spans studies in cancer, cardiovascular diseases, and neurodegenerative disorders.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionY-33075 hydrochloride is a selective inhibitor of the Rho-associated protein kinase (ROCK). It exhibits enhanced potency compared to its predecessor, Y-27632, with an IC50 of 3.6 nM. This compound is utilized in research to elucidate the role of ROCK in various biological processes, including cellular motility, proliferation, and apoptosis. Its application spans studies in cancer, cardiovascular diseases, and neurodegenerative disorders.
Product Information
Catalog NumA36828
FormulaC16H17ClN4O
Molecular Weight316.79
CAS Number471843-75-1
SMILESO=C(C1=CC=C([C@@H](C)N)C=C1)NC2=C3C(NC=C3)=NC=C2.Cl
SynonymsY-39983
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