Y134 is a selective estrogen receptor modulator (SERM) that exhibits significant antagonist activity against both ERα and ERβ. With a remarkable 121.1-fold selectivity for ERα (Ki=0.09 nM) compared to ERβ (Ki=11.31 nM), Y134 effectively inhibits estrogen-stimulated proliferation in ER-positive human breast cancer cells. This compound is valuable for research applications focused on breast cancer biology and the modulation of estrogenic signaling pathways.
Y134 is a selective estrogen receptor modulator (SERM) that exhibits significant antagonist activity against both ERα and ERβ. With a remarkable 121.1-fold selectivity for ERα (Ki=0.09 nM) compared to ERβ (Ki=11.31 nM), Y134 effectively inhibits estrogen-stimulated proliferation in ER-positive human breast cancer cells. This compound is valuable for research applications focused on breast cancer biology and the modulation of estrogenic signaling pathways.
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