YF-2

Catalog No.: A21018

histone acetyltransferase activator

YF-2

YF-2 Chemical Structure

CAS NO. 1311423-89-8

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $315.00

Special Price $252.00

10 mg

Regular Price: $543.00

Special Price $434.40

50 mg

Regular Price: $1,610.00

Special Price $1,288.00

100 mg

Regular Price: $3,220.00

Special Price $2,576.00

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Biological Activity

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.
In vitro DMSO 78 mg/mL (181.03 mM)
Water 78 mg/mL (181.03 mM)
Ethanol 78 mg/mL (181.03 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.21 mL 116.05 mL 232.1 mL
0.5 mM 4.64 mL 23.21 mL 46.42 mL
1 mM 2.32 mL 11.6 mL 23.21 mL
5 mM 0.46 mL 2.32 mL 4.64 mL

*The above data is based on the productmolecular weight 430.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21018
Actions Activator
CAS No. 1311423-89-8
Formula C20H22ClF3N2O3
M. Wt 430.85
Purity >98%
Synonyms YF2, YF 2
SMILES O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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