YF-2

Catalog No.: A21018

histone acetyltransferase activator

YF-2

YF-2 Chemical Structure

CAS NO. 1311423-89-8

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.

Availability: In stock

Package Price Qty
5 mg
$315.00
10 mg
$543.00
50 mg
$1,610.00
100 mg
$3,220.00
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Biological Activity

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.21 mL 116.05 mL 232.1 mL
0.5 mM 4.64 mL 23.21 mL 46.42 mL
1 mM 2.32 mL 11.6 mL 23.21 mL
5 mM 0.46 mL 2.32 mL 4.64 mL

*The above data is based on the productmolecular weight 430.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21018
Actions Activator
M. Wt 430.85
Formula C20H22ClF3N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1311423-89-8
Synonyms YF2, YF 2
SMILES O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C

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