YH18968 is an orally active GPR119 agonist, exhibiting an EC50 of 2.8 nM for cAMP accumulation. This compound enhances intracellular cyclic adenosine monophosphate levels, promotes glucagon-like peptide-1 secretion from intestinal L cells, and stimulates glucose-dependent insulin secretion from pancreatic β cells. YH18968 has been shown to improve glucose tolerance in both normal and diet-induced obese mouse models, making it a valuable reagent for research aimed at understanding and managing type 2 diabetes.
YH18968 is an orally active GPR119 agonist, exhibiting an EC50 of 2.8 nM for cAMP accumulation. This compound enhances intracellular cyclic adenosine monophosphate levels, promotes glucagon-like peptide-1 secretion from intestinal L cells, and stimulates glucose-dependent insulin secretion from pancreatic β cells. YH18968 has been shown to improve glucose tolerance in both normal and diet-induced obese mouse models, making it a valuable reagent for research aimed at understanding and managing type 2 diabetes.
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