YM-16638 is a potent orally active leukotriene antagonist targeting leukotrienes C4, D4, and E4. It effectively inhibits their production in guinea pig trachea with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. Additionally, YM-16638 demonstrates a dose-dependent inhibitory effect on both early and late antigen-induced respiratory responses in allergic sheep, making it a valuable tool for research in respiratory and allergic conditions.
YM-16638 is a potent orally active leukotriene antagonist targeting leukotrienes C4, D4, and E4. It effectively inhibits their production in guinea pig trachea with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. Additionally, YM-16638 demonstrates a dose-dependent inhibitory effect on both early and late antigen-induced respiratory responses in allergic sheep, making it a valuable tool for research in respiratory and allergic conditions.
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