YM-44778 is a selective antagonist of tachykinin receptors, specifically blocking NK1, NK2, and NK3 receptors with pKi values of 8.08, 8.55, and 8.24, respectively. This compound demonstrates significant inhibition of bladder pressure elevation induced by the neuropeptide substance [Sar9,Met(O2)11]-P in anesthetized rat models. Its pharmacological profile makes YM-44778 valuable for research in bladder function and disorders related to tachykinin signaling.
YM-44778 is a selective antagonist of tachykinin receptors, specifically blocking NK1, NK2, and NK3 receptors with pKi values of 8.08, 8.55, and 8.24, respectively. This compound demonstrates significant inhibition of bladder pressure elevation induced by the neuropeptide substance [Sar9,Met(O2)11]-P in anesthetized rat models. Its pharmacological profile makes YM-44778 valuable for research in bladder function and disorders related to tachykinin signaling.
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