YM580 is a selective antagonist of the Androgen Receptor (AR), exhibiting potent activity with an IC50 of 0.11 μM and Ki values of 4.6 nM for human AR and 6.2 nM for rat AR. It demonstrates high selectivity over other steroid hormone receptors, including PR, GR, and ERα, with Kis greater than 3300 nM. In vivo studies show that YM580 effectively reduces ventral prostate weight in mature intact rats in a dose-dependent manner while maintaining serum testosterone levels. This compound is valuable for research into prostate cancer and androgen-related pathways.
YM580 is a selective antagonist of the Androgen Receptor (AR), exhibiting potent activity with an IC50 of 0.11 μM and Ki values of 4.6 nM for human AR and 6.2 nM for rat AR. It demonstrates high selectivity over other steroid hormone receptors, including PR, GR, and ERα, with Kis greater than 3300 nM. In vivo studies show that YM580 effectively reduces ventral prostate weight in mature intact rats in a dose-dependent manner while maintaining serum testosterone levels. This compound is valuable for research into prostate cancer and androgen-related pathways.
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