Z-Gly-Pro-Phe-Leu-CHO is a tetrapeptide aldehyde that serves as a highly selective and potent inhibitor of the proteasome. It demonstrates significant inhibition with Ki values of 1.5 µM for branched-chain amino acid-preferring activities, 2.3 µM for small neutral amino acid-preferring activities, and 40.5 µM for chymotrypsin-like activities, with an IC50 of 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity. This compound is valuable for research applications focusing on proteasomal functions and related pathways in cellular processes.
Z-Gly-Pro-Phe-Leu-CHO is a tetrapeptide aldehyde that serves as a highly selective and potent inhibitor of the proteasome. It demonstrates significant inhibition with Ki values of 1.5 µM for branched-chain amino acid-preferring activities, 2.3 µM for small neutral amino acid-preferring activities, and 40.5 µM for chymotrypsin-like activities, with an IC50 of 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity. This compound is valuable for research applications focusing on proteasomal functions and related pathways in cellular processes.
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