Zaprinast is a selective inhibitor of cGMP-selective Phosphodiesterase 5 (PDE5), leading to a notable increase in cGMP levels in cardiac myocytes. In addition to its PDE5 inhibition, Zaprinast acts as an agonist for G protein-coupled receptor 35 (GPR35), demonstrating strong activation in rat models and moderate activation in human models. This compound exhibits antiproliferative and proapoptotic effects, making it valuable for research applications focused on vascular remodeling and related cardiovascular studies.
Zaprinast is a selective inhibitor of cGMP-selective Phosphodiesterase 5 (PDE5), leading to a notable increase in cGMP levels in cardiac myocytes. In addition to its PDE5 inhibition, Zaprinast acts as an agonist for G protein-coupled receptor 35 (GPR35), demonstrating strong activation in rat models and moderate activation in human models. This compound exhibits antiproliferative and proapoptotic effects, making it valuable for research applications focused on vascular remodeling and related cardiovascular studies.
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