ZD 9379 sodium acts as a competitive antagonist at the glycine-binding site of the NMDA receptor, exhibiting an IC50 value of 75 nM for the glutamate site. This compound inhibits glycine binding, mitigating excitotoxicity and demonstrating therapeutic potential in conditions such as acute ischemic stroke. ZD 9379 sodium reduces the frequency of cortical spreading depression, decreases infarct volume, and enhances neurological function in preclinical mouse models, making it a valuable tool for research in neuroprotection and stroke mechanisms.
ZD 9379 sodium acts as a competitive antagonist at the glycine-binding site of the NMDA receptor, exhibiting an IC50 value of 75 nM for the glutamate site. This compound inhibits glycine binding, mitigating excitotoxicity and demonstrating therapeutic potential in conditions such as acute ischemic stroke. ZD 9379 sodium reduces the frequency of cortical spreading depression, decreases infarct volume, and enhances neurological function in preclinical mouse models, making it a valuable tool for research in neuroprotection and stroke mechanisms.
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