ZK164015 is an estrogen-glucocorticoid receptor chimera that primarily targets the estrogen receptor (ER). This compound serves as a valuable screening tool to assess tissue-selective estrogen activity and has been utilized to investigate ER function in osteoblasts. Studies involving osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cell lines demonstrated that ZK164015 modulates ERE-luciferase reporter activity and influences nuclear mobility, revealing its distinct effects in response to ER agonists.
ZK164015 is an estrogen-glucocorticoid receptor chimera that primarily targets the estrogen receptor (ER). This compound serves as a valuable screening tool to assess tissue-selective estrogen activity and has been utilized to investigate ER function in osteoblasts. Studies involving osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cell lines demonstrated that ZK164015 modulates ERE-luciferase reporter activity and influences nuclear mobility, revealing its distinct effects in response to ER agonists.
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