ZLHQ-5f

Name: ZLHQ-5f
Brand: Adooq Bioscience
SKU: A32109
Rating: 5 (288 reviews)

Catalog No.: A32109

CDK2/Topo I Inhibitor

ZLHQ-5f is a dual inhibitor of Cyclin-dependent kinase 2 (CDK2) and Topoisomerase I (Topo I), exhibiting an IC50 of 0.145 μM against CDK2/CycA2. This compound effectively induces S-phase cell cycle arrest and triggers apoptosis in HCT116 cancer cells. Its favorable safety profile supports its potential applications in cancer research and therapeutic development.

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ZLHQ-5f 2851977-85-8 CDK2/Topo I Inhibitor

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Biological Activity

Description	ZLHQ-5f is a dual inhibitor of Cyclin-dependent kinase 2 (CDK2) and Topoisomerase I (Topo I), exhibiting an IC50 of 0.145 μM against CDK2/CycA2. This compound effectively induces S-phase cell cycle arrest and triggers apoptosis in HCT116 cancer cells. Its favorable safety profile supports its potential applications in cancer research and therapeutic development.

Product Information

Catalog Num	A32109
Formula	C28H25N5O2
Molecular Weight	463.53
CAS Number	2851977-85-8
SMILES	N[C@H]1CCN(C1)C2=C3OC4=C(C3=NC5=CC=C(C=C52)C6=CC(NC(C7CC7)=O)=NC=C6)C=CC=C4

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