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ZM 39923 HCl is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 M, respectively)
Targets
| TGM2 | JAK3 | EGFR | JAK1 | |
| 10 nM | 7.1(pIC50) | 5.6(pIC50) | 4.4(pIC50) |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.18 mL | 135.91 mL | 271.81 mL |
| 0.5 mM | 5.44 mL | 27.18 mL | 54.36 mL |
| 1 mM | 2.72 mL | 13.59 mL | 27.18 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.44 mL |
*The above data is based on the productmolecular weight 367.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13509 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 367.9 |
| Formula | C23H25NOHCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1021868-92-7 |
| Synonyms | JAK3 Inhibitor IV |
| SMILES | O=C(CCN(CC1=CC=CC=C1)C(C)C)C2=CC3=CC=CC=C3C=C2.Cl |
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