ZX-29 is a selective autophagy inducer that targets the ALK pathway, exhibiting potent inhibition with IC50 values of 2.1 nM, 1.3 nM, and 3.9 nM for wild-type ALK and its L1196M and G1202R mutations, respectively. This compound triggers apoptosis through the induction of endoplasmic reticulum stress while effectively overcoming resistance associated with ALK mutations. Additionally, ZX-29 promotes protective autophagy and demonstrates significant antitumor activity, making it a valuable tool for research into cancer therapies targeting the ALK signaling pathway.
ZX-29 is a selective autophagy inducer that targets the ALK pathway, exhibiting potent inhibition with IC50 values of 2.1 nM, 1.3 nM, and 3.9 nM for wild-type ALK and its L1196M and G1202R mutations, respectively. This compound triggers apoptosis through the induction of endoplasmic reticulum stress while effectively overcoming resistance associated with ALK mutations. Additionally, ZX-29 promotes protective autophagy and demonstrates significant antitumor activity, making it a valuable tool for research into cancer therapies targeting the ALK signaling pathway.
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