A-674563

Catalog No.: A11034
Akt inhibitor
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
Grouped product items
Product Name Price Stock Qty
A-674563 5mg
$140.00
In stock
A-674563 10mg
$220.00
In stock
A-674563 25mg
$400.00
In stock
A-674563 50mg
$650.00
In stock
A-674563 10mM * 1mL in DMSO
$159.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's A-674563 has been cited by 3 publications
  • Kobayashi T, .et al. , Biochem Biophys Res Commun, 2018, Jan 1;495(1):1468-1475 PMID: 29196261
  • Lin Xu, .et al. , Biochem Biophys Res Commun, 2016, Apr 15;472(4):662-8 PMID: 26920060
  • Zou Y, .et al. , Biochem Biophys Res Commun, 2016, Aug 12;477(1):1-8 PMID: 26970307
  • Biological Activity
    Discription A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A11034
    Formula C22H22N4O
    Molecular Weight 358.4
    CAS Number 552325-73-2
    SMILES CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[C@H](CC4=CC=CC=C4)N
    Synonyms A674563
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 71 mg/mL (198.08 mM)
    Water 71 mg/mL (198.08 mM)
    Ethanol 18 mg/mL (50.21 mM)
    In vivo Saline 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 27.9 mL 139.51 mL 279.02 mL
    0.5 mM 5.58 mL 27.9 mL 55.8 mL
    1 mM 2.79 mL 13.95 mL 27.9 mL
    5 mM 0.56 mL 2.79 mL 5.58 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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