A-674563

ON SALE

Akt inhibitor

0 Customer Reviews
Catalog No. A11034

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
A-674563 5mg A11034-5

Regular Price: $140.00

Special Price: $119.00

A-674563 10mg A11034-10

Regular Price: $220.00

Special Price: $187.00

A-674563 25mg A11034-25

Regular Price: $400.00

Special Price: $340.00

A-674563 50mg A11034-50

Regular Price: $650.00

Special Price: $552.50

A-674563 10mM * 1mL in DMSO A11034-10mM-D

Regular Price: $159.00

Special Price: $135.15

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

A-674563

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A11034
Actions Inhibitor
M. Wt 358.4
Formula C22H22N4O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 552325-73-2
Synonyms A674563
SMILES code CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[[email protected]](CC4=CC=CC=C4)N
Chemical Name (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine

Biological Activity

Description
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
Targets
Target Value
Akt1ki: 11nM
PKAki: 16nM
CDK2ki: 46nM
GSK-3βki: 110nM
ERK2ki: 260nM
PKCδki: 360nM
RSK2ki: 580nM
MAPK-AP2ki: 1.1μM
PKCγki: 1.2μM
FLT1ki: >2.2μM
Chk1ki: 2.6μM
KDRki: >3.7μM
CK2ki: 5.4μM
c-Kitki: >5.8μM
Srcki: 13μM
PDK-1ki: >20μM

Solubility

Solubility (25°C) * In vitro DMSO 72 mg/mL (200.87 mM)
Water 72 mg/mL (200.87 mM)
Ethanol 18 mg/mL (50.21 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Similar product(s)


Keywords:buy A-674563 | A-674563 Supplier | purchase A-674563 | A-674563 cost | A-674563 manufacturer | order A-674563 | A-674563 distributor | buy 552325-73-2| 552325-73-2 Supplier | purchase 552325-73-2 | 552325-73-2 cost | 552325-73-2 manufacturer | order 552325-73-2 | 552325-73-2 distributor