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Amyloid b-Peptide (1-42) (human)

Name: Amyloid b-Peptide (1-42) (human)
Brand: Adooq Bioscience
SKU: A14075
Availability: InStock
Rating: 5 (14 reviews)

Cat. No. A14075 CAS 107761-42-2

Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

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Biological Activity

In Vitro

Recommends the following protocol for re-suspending 100 µg of peptide into a 1 mg/mL solution:

1. Bring dried peptide to room temperature for 10 minutes.
2. Add 7.5 µL cold filter sterilized 1% Ammonium hydroxide (NH4OH) to the peptide aliquot, mix well by pipetting up and down. Take care to scrape inside lower walls of tube to ensure complete re-suspension of the film.
3. Add 92.5 µL of cold filter sterilized PBS. Optional - Centrifuge monomer 14,000 x g at 4 C for approximately 5-10 minutes and keep the supernatant to remove any material that was not fully re-suspended.
4. Keep monomer on ice and use immediately.

* While it is not recommended, depending on your application small aliquots (≤ 50 μL) can be frozen and kept for up to 2 weeks at -80°C. However, aggregate should be removed by centrifugation at 4oC upon thawing.

Specifications

Manufacturer	Adooq Bioscience
CAS Number	107761-42-2
Formula	C₂₀₃H₃₁₁N₅₅O₆₀S
Molecular Weight	4514.08
SMILES	[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

14 publications citing this product

Aysu Şen, .et al. , Iranian Journal of Basic Medical Sciences, 2026, 29: 1241-1248
Naveen Kumar, .et al. , ACS Chem Neurosci, 2025, Dec 17;16(24):4751-4768 PMID: 41331838
Bahar Sarikamis Johnson, .et al. , Metab Brain Dis, 2025, Oct 29;40(8):300 PMID: 41160319
Kailash Jangid, .et al. , RSC Medicinal Chemistry, 2025, Sep 17 PMID: 41122453
Kailash Jangid, .et al. , Comput Biol Med, 2025, Sep;196(Pt A):110762 PMID: 40664126
Nilufer Ercin, .et al. , Mol Neurobiol, 2025, Sep;62(9):11030-11046 PMID: 40257688
Naveen Kumar, .et al. , RSC Med Chem, 2024, Sep 24 PMID: 39399311
Naveen Kumar, .et al. , ACS Chem Neurosci, 2024, May 25 PMID: 38795037
Yinhua Ni, .et al. , J Agric Food Chem, 2024, Jul 31;72(30):16708-16725 PMID: 39016108
Seda Onder, .et al. , Chem Biol Interact, 2022, Aug 25;363:110029 PMID: 35779611
Seham S El-Hawary, .et al. , Food Funct, 2022, Sep 7;12(17):8078-8089 PMID: 34286787
Zsolt Datki, .et al. , Int J Biol Macromol, 2022, Jan 7;201:262-269 PMID: 34999044
Suresh K.Bowroju, .et al. , Bioorg Med Chem, 2021, 45:116311 PMID: 34304133
Zsolt Datki, .et al. , Ecotoxicol Environ Saf, 2021, Jan 15;208:111666 PMID: 33396176

Showing 10 of 14 publications

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