Target & Activity
| Target | Activity | Value |
|---|---|---|
| PKC | Ki | 11.9 nM |
Fig. 1 · Structure
Documents & Downloads
alpha-Amyloid Precursor Protein Modulator
Cat. No.
A13094
CAS
497259-23-1
alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 497259-23-1 |
| Formula | C27H30F3N3O3 |
| Molecular Weight | 501.5 |
| Synonyms | PKC Activator V |
| SMILES | CC(C)[C@H]1C(=O)N[C@@H](CC2=C(N1C)C=CC(=C2)NC(=O)/C=C/C=C/C3=CC=C(C=C3)C(F)(F)F)CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Publications
1 publication citing this product
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Shusen Wang, .et al. , Cell, 2024, Oct 31;187(22):6152-6164 PMID: 39326417