AT13148

multi-AGC kinase inhibitor

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Catalog No. A12464

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT13148 5mg A12464-5
$100.00
AT13148 10mg A12464-10
$160.00
AT13148 25mg A12464-25
$350.00
AT13148 10mM * 1mL in DMSO A12464-10mM-D
$105.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.

AT13148

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Chemical Information

Catalog Num A12464
Actions Inhibitor
M. Wt 313.78
Formula C17H16ClN3O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1056901-62-2
Synonyms AT 13148, AT-13148
SMILES code C1=CC(=CC=C1C2=CNN=C2)[[email protected]@](CN)(C3=CC=C(C=C3)Cl)O
Chemical Name (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol

Biological Activity

Description
AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
Targets
Target Value
PKAIC50: 3nM
ROCK2IC50: 4nM
ROCK1IC50: 6nM
p70S6KIC50: 8nM
Akt1IC50: 38nM
Akt3IC50: 50nM
SGK3IC50: 63nM
RSK1IC50: 85nM
Akt2IC50: 402nM
Chk2IC50: 860nM
AuroraBIC50: 1860nM

Solubility

Solubility (25°C)* In vitro DMSO 62 mg/mL (197.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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