CUDC-101

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HDAC inhibitor

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Catalog No. A10246

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
CUDC-101 10mg A10246-10

Regular Price: $70.00

Special Price: $56.00

CUDC-101 50mg A10246-50

Regular Price: $260.00

Special Price: $208.00

CUDC-101 100mg A10246-100

Regular Price: $480.00

Special Price: $384.00

CUDC-101 200mg A10246-200

Regular Price: $720.00

Special Price: $576.00

CUDC-101 10mM * 1mL in DMSO A10246-10mM-D

Regular Price: $89.00

Special Price: $71.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.

CUDC-101

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Chemical Information

Catalog Num A10246
Actions Inhibitor
M. Wt 434.5
Formula C24H26N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1012054-59-9
Synonyms CUDC101
SMILES code COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
Chemical Name 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide

Biological Activity

Description
CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.
Targets
Target Value
EGFRIC50: 2.4nM
HDACIC50: 4.4nM
HDAC1IC50: 4.5nM
HDAC6IC50: 5.1nM
HDAC3IC50: 9.1nM
HDAC5IC50: 11.4nM
HDAC2IC50: 12.6nM
HDAC4IC50: 13.2nM
HER2IC50: 15.7nM
HDAC10IC50: 26.1nM
HDAC9IC50: 67.2nM
HDAC8IC50: 79.8nM
HDAC7IC50: 373nM

Solubility

Solubility (25°C) * In vitro DMSO 20 mg/mL (46.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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