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Gamma secretase inhibitor

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Catalog No. A11176

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Product Name Catalog No. Price Qty
LY-411575 5mg A11176-5

Regular Price: $90.00

Special Price: $72.00

LY-411575 10mg A11176-10

Regular Price: $160.00

Special Price: $128.00

LY-411575 50mg A11176-50

Regular Price: $580.00

Special Price: $464.00

LY-411575 100mg A11176-100

Regular Price: $960.00

Special Price: $768.00

LY-411575 10mM * 1mL in DMSO A11176-10mM-D

Regular Price: $120.00

Special Price: $96.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.


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Chemical Information

Catalog Num A11176
Actions Inhibitor
M. Wt 479.48
Formula C26H23F2N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 209984-57-6
Synonyms LY411575
SMILES code C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[[email protected]](C4=CC(=CC(=C4)F)F)O
Chemical Name (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide

Biological Activity


LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE) γ secretase (cell-based) (HEK293 cells expressing either APP or NδE) Notch S3 cleavage (HEK293 cells expressing either APP or NδE)
0.078 nM0.082 nM0.39 nM


Solubility (25°C) * In vitro DMSO 95 mg/mL (198.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol 95 mg/mL (198.13 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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