LY-411575
LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.
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Adooq Products cited in reputable paper
Adooq's LY-411575 has been cited by 6 publications
- Haiwen Yu, .et al. , Immunol Invest, 2023, Feb;52(2):241-255 PMID: 36562737
- Wojciech J Szlachcic, .et al. , iScience, 2022, Jul 15;25(7) PMID: 35756892
- Zhang ZH, .et al. , APMIS, 2019, Jul 5 PMID: 31274210
- Bo Pang, .et al. , Biosci Rep, 2018, Dec 21; 38(6): BSR20181922 PMID: 30473538
- Shuo Li, .et al. , Int Immunopharmacol, 2018, Oct;63:129-136 PMID: 30086535
- Jiang BC, .et al. , Viral Immunol, 2017, Sep;30(7):522-532 PMID: 28410452
Biological Activity
| Description | LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor. | |||||
|---|---|---|---|---|---|---|
| Targets |
| |||||
| Cell Research |
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Product Information
| Catalog Num | A11176 |
|---|---|
| Formula | C26H23F2N3O4 |
| Molecular Weight | 479.48 |
| CAS Number | 209984-57-6 |
| SMILES | C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O |
| Synonyms | LY411575 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 94 mg/mL (196.04 mM) | |
| Water | Insoluble | ||
| Ethanol | 13 mg/mL (27.11 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.86 mL | 104.28 mL | 208.56 mL |
| 0.5 mM | 4.17 mL | 20.86 mL | 41.71 mL |
| 1 mM | 2.09 mL | 10.43 mL | 20.86 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.17 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
