γ-Secretase

Cat. No.

A11176

CAS No.

209984-57-6

LY-411575

LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

Cat. No.

A10288

CAS No.

208255-80-5

DAPT (GSI-IX)

Synonyms: GSIIX

DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.

Cat. No.

A10802

CAS No.

847925-91-1

RO4929097

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.

Cat. No.

A10836

CAS No.

425386-60-3

Semagacestat (LY450139)

Synonyms: LY-450139

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.

Cat. No.

A11174

CAS No.

209984-56-5

YO-01027

Synonyms: Dibenzazepine; Deshydroxy LY 411575

YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.

Cat. No.

A11393

CAS No.

870843-42-8

E 2012

E 2012 is γ-secretase inhibitor.

Cat. No.

A12444

CAS No.

290315-45-6

BMS 299897

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.

Cat. No.

A13815

CAS No.

313967-18-9

FLI-06

FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.

Cat. No.

A10157

CAS No.

1146699-66-2

Avagacestat (BMS-708163)

Synonyms: BMS-708163

BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.

Cat. No.

A11194

CAS No.

471905-41-6

MK-0752

MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.

Cat. No.

A11258

CAS No.

769169-27-9

Begacestat (GSI-953)

Synonyms: GSI953

Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Cat. No.

A11259

CAS No.

1290543-63-3

Nirogacestat (PF-03084014)

Synonyms: PF 03084014

PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM .

Cat. No.

A11337

CAS No.

935525-13-6

BMS 433796

BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.

Cat. No.

A11425

CAS No.

1172637-87-4

gamma-secretase modulator 1

gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.

Cat. No.

A11427

CAS No.

1093978-89-2

gamma-secretase modulator 2

gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.

Cat. No.

A12433

CAS No.

51543-40-9

Flurizan

Synonyms: (R)-Flurbiprofen; MPC 7869; Tarenflurbil

Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.

Cat. No.

A13217

CAS No.

1257395-14-4

TC-E 5006

TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.

Cat. No.

A13662

CAS No.

91503-79-6

Flurbiprofen Axetil

Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).

Cat. No.

A13669

CAS No.

2195361-33-0

SPL-707

SPL-707 is a potent, selective and orally available signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 80 nM.

Cat. No.

A15090

CAS No.

1431697-84-5

gamma-secretase modulator 3

gamma-secretase modulator 3 is a gamma-secretase modulator.

Cat. No.

A15296

CAS No.

173550-33-9

Compound W

Synonyms: CW3,5-Bis(4-nitrophenoxy)benzoic acid

Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.

Cat. No.

A15301

CAS No.

62252-26-0

JLK 6

JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.

Cat. No.

A15304

CAS No.

677772-84-8

MRK 560

MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.

Cat. No.

A15899

CAS No.

292632-98-5

L-685458

Synonyms: L685,458

L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.

Cat. No.

A16113

CAS No.

1286770-55-5

Verubecestat (MK-8931)

Synonyms: MK-8931

Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.