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Gamma-secretase inhibitor

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Catalog No. A11194

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
MK-0752 5mg A11194-5

Regular Price: $150.00

Special Price: $120.00

MK-0752 10mg A11194-10

Regular Price: $250.00

Special Price: $200.00

MK-0752 50mg A11194-50

Regular Price: $550.00

Special Price: $440.00

MK-0752 100mg A11194-100

Regular Price: $900.00

Special Price: $720.00

MK-0752 10mM * 1mL in DMSO A11194-10mM-D

Regular Price: $192.00

Special Price: $153.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.


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Chemical Information

Catalog Num A11194
Actions Inhibitor
M. Wt 442.9
Formula C21H21ClF2O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 471905-41-6
Synonyms MK0752
SMILES code C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
Chemical Name cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

Biological Activity

MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.


Solubility (25°C) * In vitro DMSO 89 mg/mL (200.94 mM)
Water <1 mg/mL (<1 mM)
Ethanol 45 mg/mL (101.6 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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