PF-04691502

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PI3K/mTOR Inhibitor

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Catalog No. A11024

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-04691502 5mg A11024-5

Regular Price: $70.00

Special Price: $59.50

PF-04691502 10mg A11024-10

Regular Price: $120.00

Special Price: $102.00

PF-04691502 50mg A11024-50

Regular Price: $400.00

Special Price: $340.00

PF-04691502 100mg A11024-100

Regular Price: $720.00

Special Price: $612.00

PF-04691502 10mM * 1mL in DMSO A11024-10mM-D

Regular Price: $85.00

Special Price: $72.25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway.

PF-04691502

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Chemical Information

Catalog Num A11024
Actions Inhibitor
M. Wt 425.5
Formula C22H27N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1013101-36-4
Synonyms PF04691502
SMILES code CC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC
Chemical Name 2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Biological Activity

Description
PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway.
Targets
Target Value
PI3Kδki: 1.6nM
PI3Kαki: 1.8nM
PI3Kγki: 1.9nM
PI3Kβki: 2.1nM
P-Akt(S473)IC50: 3.8nM
P-Akt(T308)IC50: 7.5nM
mTORki: 16nM

Solubility

Solubility (25°C)* In vitro DMSO 14 mg/mL (32.9 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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