PI-103

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PI3K Inhibitor

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Catalog No. A10726

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PI-103 5mg A10726-5
$50.00
PI-103 10mg A10726-10
$70.00
PI-103 25mg A10726-25
$140.00
PI-103 50mg A10726-50
$220.00
PI-103 10mM * 1mL in DMSO A10726-10mM-D
$94.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.

PI-103

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Chemical Information

Catalog Num A10726
Actions Inhibitor
M. Wt 348.4
Formula C19H16N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 371935-74-9
Synonyms PI103
SMILES code C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O
Chemical Name 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol

Biological Activity

Description
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.
Targets
Target Value
p110αIC50: 2nM
p110βIC50: 3nM
p110δIC50: 3nM
p110γIC50: 15nM
DNA-PKIC50: 23nM
mTORIC50: 30nM

Solubility

Solubility (25°C) * In vitro DMSO 24 mg/mL (68.89 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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