Semagacestat (LY450139)

Catalog No.: A10836
Gamma-secretase inhibitor
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
Grouped product items
Product Name Price Stock Qty
Semagacestat 5mg
$63.00
In stock
Semagacestat 10mg
$107.00
In stock
Semagacestat 50mg
$315.00
In stock
Semagacestat 100mg
$1,071.00
In stock
Semagacestat (LY450139) 10mM * 1mL in DMSO
$120.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Semagacestat (LY450139) has been cited by 1 publications
  • Yesuvadian R, .et al. , Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079
  • Biological Activity
    Discription Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
    Targets
    Target Value
    Product Information
    Catalog Num A10836
    Formula C19H27N3O4
    Molecular Weight 361.4
    CAS Number 425386-60-3
    SMILES C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O
    Synonyms LY-450139
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 66 mg/mL (182.6 mM)
    Water Insoluble
    Ethanol 38 mg/mL (105.13 mM)
    In vivo 0.5% methylcellulose 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 27.67 mL 138.35 mL 276.7 mL
    0.5 mM 5.53 mL 27.67 mL 55.34 mL
    1 mM 2.77 mL 13.84 mL 27.67 mL
    5 mM 0.55 mL 2.77 mL 5.53 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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