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|Storage||at -20°C 2 years|
|SMILES code||C[C@@H](C(=O)N[[email protected]]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[[email protected]](C(C)C)O|
|Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.|
|Solubility (25°C) *||In vitro||DMSO||72 mg/mL (199.2 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||41 mg/mL (113.43 mM)|
|In vivo||0.5% methylcellulose||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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