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- Y Zhang ,etc. FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia. Journal of pharmacokinetics and pharmacodynamics, 2014, 41(6), 675-691.
- Z Li ,etc. Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. Journal of medicinal chemistry, 2014, 57(8), 3430-3449.
- C Li ,etc. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia. Molecular cancer therapeutics, 2015, 14(2), 375-383.
- K Keegan ,etc. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Molecular cancer therapeutics, 2014, 13(4), 880-889.
|Solubility||DMSO>127mg/mL Water <1mg/mL Ethanol <1mg/mL|
|Storage||at -20°C 2 years|
|Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.|
|Solubility (25°C)*||In vitro||DMSO||63 mg/mL heating (135.53 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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