Sorafenib

Name: Sorafenib
SKU: A17857
Price: 25 USD
Rating: 5 (288 reviews)

Catalog No.: A17857

Raf/VEGFR3 inhibitor

Sorafenib (Bay 43-9006) is a potent, orally active multikinase inhibitor with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

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Grouped product items
Size	Price	Stock
50mg	$25.00	In stock
100mg	$40.00	In stock
500mg	$55.00	In stock
1g	$85.00	In stock
*10mM 1mL in DMSO**	$25.00	In stock
Bulk Size	Bulk Discount

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Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

Other Forms of Sorafenib

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Biological Activity

Discription

Sorafenib (Bay 43-9006) is a potent, orally active multikinase inhibitor with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

Product Information

Catalog Num	A17857
Formula	C21H16ClF3N4O3
Molecular Weight	464.83
CAS Number	284461-73-0
SMILES	O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Synonyms	Bay 43-9006, Bay-43-9006, Bay43-9006
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 59 mg/mL (126.92 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+45%PEG400+50%H2O	0.35 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.51 mL	107.57 mL	215.13 mL
0.5 mM	4.3 mL	21.51 mL	43.03 mL
1 mM	2.15 mL	10.76 mL	21.51 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

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