Sorafenib

Catalog No.: A17857

multikinase inhibitor

Sorafenib

Sorafenib Chemical Structure

CAS NO. 284461-73-0

Sorafenib (Bay 43-9006) is a potent, orally active multikinase inhibitor with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

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100 mg

Regular Price: $54.00

Special Price $43.20

500 mg

Regular Price: $162.00

Special Price $129.60

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Biological Activity

Sorafenib (Bay 43-9006) is a potent, orally active multikinase inhibitor with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
In vitro (25°C) DMSO Warmed: 59 mg/mL (126.92 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+45%PEG400+50%H2O 0.35 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.51 mL 107.57 mL 215.13 mL
0.5 mM 4.3 mL 21.51 mL 43.03 mL
1 mM 2.15 mL 10.76 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 464.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17857
Actions Inhibitor
CAS No. 284461-73-0
Formula C21H16ClF3N4O3
M. Wt 464.83
Solubility DMSO
Purity >98%
Synonyms Bay 43-9006, Bay-43-9006, Bay43-9006
SMILES O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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