Sorafenib

Catalog No.: A17857

multikinase inhibitor

Sorafenib

Sorafenib Chemical Structure

CAS NO. 284461-73-0

Sorafenib (Bay 43-9006) is a potent, orally active multikinase inhibitor with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.

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500 mg
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Biological Activity

Sorafenib (Bay 43-9006) is a potent, orally active multikinase inhibitor with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.51 mL 107.57 mL 215.13 mL
0.5 mM 4.3 mL 21.51 mL 43.03 mL
1 mM 2.15 mL 10.76 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 464.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17857
Actions Inhibitor
M. Wt 464.83
Formula C21H16ClF3N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 284461-73-0
Synonyms Bay 43-9006, Bay-43-9006, Bay43-9006
SMILES O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3

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