1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. This compound features an azide moiety that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzoazacyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the development of versatile bioconjugates in chemical biology research.
1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. This compound features an azide moiety that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzoazacyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the development of versatile bioconjugates in chemical biology research.
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