1-Isothiocyanato-PEG3-azide is a versatile PEG-based PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with entities possessing DBCO or BCN groups. Its utility in conjugation chemistry supports various applications in chemical biology and drug development.
1-Isothiocyanato-PEG3-azide is a versatile PEG-based PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with entities possessing DBCO or BCN groups. Its utility in conjugation chemistry supports various applications in chemical biology and drug development.
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