16(R)-AFP 07 free acid is a potent prostaglandin analog targeting the IP receptor, which is critical for inhibiting platelet aggregation and promoting vasodilation in the pulmonary vascular system. As a 7,7-difluoroprostacyclin derivative, it exhibits high selectivity and potency for the IP receptor (Ki = 0.561 nM). While its affinity for EP receptors is significantly lower, with Ki values exceeding 100 nM for EP1-3 and >10 nM for EP4, the full extent of 16(R)-AFP 07's biological activity, particularly at the IP and EP receptors, warrants further investigation. This compound is relevant for studies exploring vascular functions and anti-thrombotic applications.
16(R)-AFP 07 free acid is a potent prostaglandin analog targeting the IP receptor, which is critical for inhibiting platelet aggregation and promoting vasodilation in the pulmonary vascular system. As a 7,7-difluoroprostacyclin derivative, it exhibits high selectivity and potency for the IP receptor (Ki = 0.561 nM). While its affinity for EP receptors is significantly lower, with Ki values exceeding 100 nM for EP1-3 and >10 nM for EP4, the full extent of 16(R)-AFP 07's biological activity, particularly at the IP and EP receptors, warrants further investigation. This compound is relevant for studies exploring vascular functions and anti-thrombotic applications.
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