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16(R)-AFP 07 free acid

Prostaglandin Analog

16(R)-AFP 07 free acid is a potent prostaglandin analog targeting the IP receptor, which is critical for inhibiting platelet aggregation and promoting vasodilation in the pulmonary vascular system. As a 7,7-difluoroprostacyclin derivative, it exhibits high selectivity and potency for the IP receptor (Ki = 0.561 nM). While its affinity for EP receptors is significantly lower, with Ki values exceeding 100 nM for EP1-3 and >10 nM for EP4, the full extent of 16(R)-AFP 07's biological activity, particularly at the IP and EP receptors, warrants further investigation. This compound is relevant for studies exploring vascular functions and anti-thrombotic applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	773825-80-2
Applications	Prostaglandin Analog
Formula	C₂₂H₃₀F₂O₅
Molecular Weight	412.47
SMILES	O=C(O)CCC/C=C1C(F)(F)[C@@]([C@@H](/C=C/[C@H](O)[C@@H](C)CC#CCC)[C@H](O)C2)([H])[C@@]2([H])O/1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.