2-Acetamidophenol, an ortho-regioisomer of Paracetamol, serves as a ferroptosis regulator, primarily influencing glutathione metabolic pathways. This compound exhibits anti-atherosclerotic properties, effectively reducing total cholesterol and triglyceride levels in zebrafish hyperlipidemia models with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol promotes the expression of genes associated with glutathione synthesis and iron ion transport, mitigates intracellular reactive oxygen species and ferrous ion accumulation, and enhances glutathione peroxidase GPX4 activity, consequently inhibiting macrophage phagocytosis of oxidized low-density lipoprotein and foam cell development.
2-Acetamidophenol, an ortho-regioisomer of Paracetamol, serves as a ferroptosis regulator, primarily influencing glutathione metabolic pathways. This compound exhibits anti-atherosclerotic properties, effectively reducing total cholesterol and triglyceride levels in zebrafish hyperlipidemia models with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol promotes the expression of genes associated with glutathione synthesis and iron ion transport, mitigates intracellular reactive oxygen species and ferrous ion accumulation, and enhances glutathione peroxidase GPX4 activity, consequently inhibiting macrophage phagocytosis of oxidized low-density lipoprotein and foam cell development.
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