3′-Azido-2′,3′-dideoxyuridine is a nucleoside analog primarily targeting human immunodeficiency virus (HIV) replication. It exhibits significant antiviral activity in human peripheral blood mononuclear cells (PBMC) while demonstrating minimal toxicity to human bone marrow cells (BMC). In addition to its role as an HIV inhibitor, 3′-Azido-2′,3′-dideoxyuridine serves as a click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
3′-Azido-2′,3′-dideoxyuridine is a nucleoside analog primarily targeting human immunodeficiency virus (HIV) replication. It exhibits significant antiviral activity in human peripheral blood mononuclear cells (PBMC) while demonstrating minimal toxicity to human bone marrow cells (BMC). In addition to its role as an HIV inhibitor, 3′-Azido-2′,3′-dideoxyuridine serves as a click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
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