4-P-PDOT is a highly selective antagonist of the Melatonin MT2 receptor, exhibiting over 300-fold greater affinity for MT2 compared to the MT1 receptor. This compound effectively inhibits melatonin-induced antioxidant activities, as evidenced by its impact on the GSH/GSSG ratio, phospho-ERK levels, Nrf2 nuclear translocation, and Nrf2 DNA-binding activity. 4-P-PDOT is a valuable tool for research into melatonin signaling pathways and oxidative stress responses.
4-P-PDOT is a highly selective antagonist of the Melatonin MT2 receptor, exhibiting over 300-fold greater affinity for MT2 compared to the MT1 receptor. This compound effectively inhibits melatonin-induced antioxidant activities, as evidenced by its impact on the GSH/GSSG ratio, phospho-ERK levels, Nrf2 nuclear translocation, and Nrf2 DNA-binding activity. 4-P-PDOT is a valuable tool for research into melatonin signaling pathways and oxidative stress responses.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
