Domatinostat (4SC-202)

Catalog No.: A14354

HDAC inhibitor

Domatinostat (4SC-202)

Domatinostat (4SC-202) Chemical Structure

CAS NO. 910462-43-0

4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $150.00

Special Price $120.00

25 mg

Regular Price: $300.00

Special Price $240.00

50 mg

Regular Price: $450.00

Special Price $360.00

10mM * 1mL in DMSO

Regular Price: $126.00

Special Price $100.80

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Biological Activity

4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity.
Targets
HDAC3 HDAC2 HDAC1
0.57 μM1.12 μM1.20 μM
In vitro (25°C) DMSO 77 mg/mL (172.06 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.35 mL 111.73 mL 223.46 mL
0.5 mM 4.47 mL 22.35 mL 44.69 mL
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

*The above data is based on the productmolecular weight 447.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14354
Actions Inhibitor
CAS No. 910462-43-0
Formula C23H21N5O3S
M. Wt 447.51
Purity >98%
Synonyms 0
SMILES CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)/C=C/C(=O)NC4=CC=CC=C4N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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