5-(Biotinamido)pentylazide is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynes. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a valuable tool for chemical research in targeted protein degradation and related applications.
5-(Biotinamido)pentylazide is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynes. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a valuable tool for chemical research in targeted protein degradation and related applications.
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