Catalog No.
Product Name
Application
Product Information
Citations
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Adenosine Analog
N-(2-Phenoxyacetyl)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits smooth muscle vasodilatory effects and has demonstrated potential in inhibiting cancer progression. It serves as a valuable tool in cancer research and studies related to vascular biology. -
Adenosine Analog
N6-Benzoyl-9-β-D-arabinofuranosyladenine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits smooth muscle vasodilatory effects and demonstrates potential in inhibiting cancer progression. It serves as a valuable tool in studies focused on cardiovascular research and oncology, enabling researchers to explore the therapeutic implications of adenosine signaling pathways. -
Adenosine Analog
8-Allylthioadenosine is an adenosine analog that primarily targets adenosine receptors. It demonstrates smooth muscle vasodilatory effects and has been implicated in inhibiting cancer progression, making it a valuable compound for oncology research. Its utility extends to studies involving vascular biology and the modulation of cellular signaling pathways. -
Adenosine Analog
3’-O-(2-Methoxyethyl)-2-aminoadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory properties and has demonstrated potential in inhibiting cancer progression. Research applications include studying vascular biology, exploring therapeutic avenues in oncology, and investigating the signaling pathways mediated by adenosine receptors. -
Adenosine Analog
3',5'-TIPS-N-Ac-Adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory activity and has potential applications in inhibiting cancer progression. It is valuable for research related to vascular biology and oncology, facilitating the study of adenosine receptor signaling pathways and their therapeutic implications. -
Adenosine Analog
8-(Methylamino)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant vasodilatory effects on smooth muscle and has been demonstrated to possess anti-cancer properties by inhibiting tumor progression. It is utilized in various research applications related to vascular biology and oncology. -
Adenosine Analog
N6-(3-Trifluoromethylbenzyl)-2’-C-methyl adenosine is an adenosine analog that primarily acts on adenosine receptors. This compound demonstrates smooth muscle vasodilatory properties and has potential applications in inhibiting cancer progression. Its structural modifications enhance its affinity and selectivity, making it a valuable reagent for research in vascular biology and oncology. -
Adenosine Analog
N6,N6-Dimethyl-xylo-adenosine is an adenosine analog with a primary mechanism of action involving modulation of adenosine receptors. This compound has demonstrated significant smooth muscle vasodilator activity and holds potential in inhibiting cancer progression. It is widely utilized in research applications focusing on vascular biology and oncology. -
Adenosine Analog
3'-β-C-Methyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits biological activity as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. It is useful in research applications focused on cardiovascular function and cancer biology. -
Adenosine Analog
9-(2-Deoxy-β-D-threo-pentofuranosyl)-9H-purin-6-amine is an adenosine analog that primarily acts on adenosine receptors. This compound exhibits smooth muscle vasodilatory activity and has demonstrated potential in inhibiting the progression of various cancers. It serves as a valuable tool in biochemical research focusing on vascular biology and oncology. -
Adenosine Analog
2-Amino-2′-O-(2-methoxy-2-oxoethyl)adenosine is an adenosine analogue targeting adenosine receptors. It exhibits smooth muscle vasodilatory effects and has demonstrated potential in inhibiting cancer progression. This compound is valuable for research applications focusing on vascular biology and cancer therapeutics. -
Adenosine Analog
2′-β-C-Methyl-2-methoxyadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits vasodilatory effects on smooth muscle and has demonstrated potential in inhibiting cancer progression. Its applications extend to research involving cardiovascular function and cancer biology, making it a valuable tool for exploring therapeutic strategies in these areas. -
Adenosine Analog
N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine is an adenosine analog that primarily targets adenosine receptors. It exhibits significant vasodilatory effects on smooth muscle and has demonstrated potential in inhibiting cancer progression. This compound is valuable in research focused on vascular biology and cancer therapeutics, offering insights into adenosine receptor signaling pathways and their clinical implications. -
Adenosine Analog
2-Amino-6-chloro-9-[(2,3,5-tri-O-benzoyl-2-C-Methyl-beta-D-ribofuranosyl)]-9H-purine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits biological activities such as promoting smooth muscle vasodilation and potentially inhibiting cancer progression. It is a valuable reagent for researchers investigating vascular biology, cancer therapeutics, and adenosine signaling pathways. -
Adenosine Analog
2-Amino-N-(3-methyl-2-buten-1-yl)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory activity and has been implicated in the inhibition of cancer progression. It serves as a valuable tool for research in vascular biology and cancer therapeutics, facilitating the exploration of adenosine receptor signaling pathways and their implications in various disease states. -
Adenosine Analog
5’-O-(4,4’-Dimethoxytrityl)-3’-O-t-butyldimethylsilyl adenosine is an adenosine analog that serves as a key modulator of adenosine receptors. This compound exhibits vasodilatory effects on smooth muscle and has potential applications in cancer research due to its ability to inhibit tumor progression. It is particularly useful for studies investigating the roles of adenosine in vascular biology and oncology. -
Adenosine Analog
2-Amino-N6,N6-dimethyl-2’-O-methyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits smooth muscle vasodilatory effects and has potential applications in inhibiting cancer progression. It is valuable for research in cardiovascular studies and oncology, providing insights into the therapeutic potential of adenosine-related pathways. -
Adenosine Analog
3’-beta-C-Methyl-N6-methyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant smooth muscle vasodilatory effects and has demonstrated potential in inhibiting cancer progression. Its unique structure allows for various research applications, particularly in studies focusing on cardiovascular function and tumor biology. -
Adenosine Analog
8-Allyloxyadenosine is an adenosine analog primarily targeting adenosine receptors. This compound exhibits significant biological activity as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. It serves as a valuable tool in research applications focused on cardiovascular health and cancer therapy. -
Adenosine Analog
2-(4-Cyanobenzyl)thioadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits potent vasodilatory effects on smooth muscle, making it of interest in cardiovascular research. Additionally, it has demonstrated potential in inhibiting cancer progression, making it a valuable tool for cancer biology studies. -
Adenosine Analog
4’-C-Methyl-N6-methyladenosine is an adenosine analogue that primarily targets adenosine receptors. This compound exhibits significant biological activity as a vasodilator, promoting smooth muscle relaxation, and has shown potential in inhibiting cancer cell progression. It serves as a valuable tool in research applications focused on vascular biology and cancer therapeutics. -
Adenosine Analog
N6-Isopentenyl-2’-C-methyladenosine is an adenosine analog that primarily acts as a vasodilator by influencing adenosine receptors. This compound has demonstrated potential in inhibiting cancer progression, making it valuable for research in oncology and cardiovascular studies. Its unique structure allows for diverse applications in studying nucleotide metabolism and therapeutic interventions targeting adenosine signaling pathways. -
Adenosine Analog
2-(4-Methylbenzyl)thioadenosine is an adenosine analog that primarily targets adenosine receptors. It is recognized for its vasodilatory effects on smooth muscle and demonstrates potential in inhibiting cancer progression. This compound serves as a valuable tool in researching adenosine receptor signaling, cardiovascular function, and cancer biology. -
Adenosine Analog
N-Propargyladenosine is an adenosine analogue that primarily acts as a vasodilator by targeting adenosine receptors. This compound exhibits significant biological activity, demonstrating potential in inhibiting cancer progression. Additionally, N-Propargyladenosine functions as a click chemistry reagent, containing an alkyne group that allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable for various chemical biology applications. -
Adenosine Analog
3′-O-Methyladenosine is an adenosine analogue that primarily targets adenosine receptors. This compound exhibits significant biological activity as a smooth muscle vasodilator and has also demonstrated potential in inhibiting cancer progression. Its applications extend to various research fields, including cardiovascular studies and oncology, making it a valuable tool for investigating adenosine-related pathways and therapeutic targets. -
Adenosine Analog
2’,3’,5’-Tri-O-acetyl adenosine is an adenosine analog that primarily targets adenosine receptors, serving as a potent smooth muscle vasodilator. This compound has been shown to exert inhibitory effects on cancer progression, making it a valuable tool in oncology research. It is useful for studying adenosine signaling pathways and their implications in various biological processes. -
Adenosine Analog
2,8-Dimethyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant vasodilatory effects on smooth muscle and has demonstrated potential in inhibiting cancer progression. It serves as a valuable tool for research in cardiovascular studies and cancer biology. -
Adenosine Analog
2-Chloro-2′-β-C-methyladenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits vasodilatory effects on smooth muscle and demonstrates the potential to inhibit cancer progression. It serves as a valuable tool for research applications focused on vascular biology and cancer therapeutics. -
Platelet Aggregation Inhibitor
U-51605 is a platelet aggregation inhibitor that targets thromboxane synthesis. It also functions as a prostaglandin I2 synthase inhibitor and has been shown to block retinal vasodilation responses induced by nitric oxide donors like NOR3. This reagent is valuable for research applications focusing on cardiovascular health and vascular biology. -
S1P₁ Agonist
PPI-4955 is a selective agonist of the sphingosine-1-phosphate receptor subtype 1 (S1P₁), displaying an EC50 of 1.62 nM. Its active phosphorylated form, PPI-4955-P, demonstrates exceptional receptor selectivity, with IC50 values of 0.23 nM for hS1P₁, 2000 nM for hS1P₃, 6.5 nM for hS1P₄, and 184 nM for hS1P₅. This compound significantly enhances in vivo phosphorylation efficiency, leading to lymphocyte reduction and a potential decrease in cardiovascular risk. PPI-4955 is applicable for research in immunomodulation and cardiovascular studies. -
Exenatide Impurity
(D-Asn28)-Exenatide is an impurity of Exenatide, which functions as a long-acting agonist of the glucagon-like peptide-1 receptor. This compound may be used in research applications focusing on peptide synthesis, quality control, and pharmacological studies involving GLP-1 receptor pathways. Its significance lies in understanding the properties and effects of Exenatide-related compounds. -
RGS Protein Inhibitor
CCG 203769 is a selective inhibitor of the regulator of G protein signaling (RGS4), effectively disrupting the RGS4-Gαo protein-protein interaction with an IC50 of 17 nM. This compound is instrumental for research applications focused on G protein-coupled signaling pathways and the modulation of G protein activity. CCG 203769 may be utilized in studies exploring the role of RGS proteins in various physiological processes and disease states. -
RGS Agonist
BMS-192364 is a selective RGS (Regulator of G Protein Signaling) agonist that targets the Gα-RGS interaction, promoting the formation of an inactive Gα-RGS complex. This compound has been shown to reduce urinary bladder contraction and enhance the activity of GTPase-activating proteins (GAPs) on Gq proteins. Additionally, BMS-192364 inhibits calcium flux, making it a valuable tool for studying signaling pathways involved in bladder function and related physiological processes. -
RGS10 Modulator
RGS10 modulator-1 functions as a potent modulator of the RGS10 protein, exhibiting significant biological activity by reversing interferon-gamma (IFNγ)-induced expression of RGS10 protein and mRNA. Additionally, this compound effectively reduces the levels of COX-2 mRNA and inducible nitric oxide synthase (iNOS) expression that are stimulated by IFNγ. RGS10 modulator-1 is a valuable tool for research exploring the regulatory mechanisms of RGS10 in inflammatory responses and related signaling pathways. -
RGS14 Inhibitor
Z55660043 is a selective inhibitor of Regulator of G protein Signaling-14 (RGS14) with an IC50 of 2.3 μM. This compound acts by non-covalently inhibiting the GTPase-accelerating protein (GAP) activity of RGS14, demonstrating a favorable safety profile without significant cytotoxic effects. Z55660043 is suitable for research focused on central nervous system and metabolic disorders, contributing to the understanding of RGS14's role in these biological processes. -
RGS4 Inhibitor
CCG-2046 is a selective inhibitor of the regulator of G-protein signaling 4 (RGS4), demonstrating an IC50 value of 4.3 μM for inhibiting the RGS4-Gαo interaction. This compound modulates G-protein signaling pathways, making it a valuable tool for studying their role in various physiological processes. CCG-2046 is suitable for research applications focused on neurobiology, cardiac function, and potential therapeutic interventions for related disorders. -
RGS Protein Inhibitor
CCG-4986 is a selective RGS protein inhibitor that covalently modifies the Cys-132 residue of RGS4, thereby inhibiting its activity. This compound is valuable for studying the implications of altered G protein-coupled receptor (GPCR) signaling in various pathological conditions, including Parkinson's disease and opioid addiction. CCG-4986 is a useful tool for researchers investigating the role of RGS proteins in cellular signaling pathways. -
RXFP1 Modulator
AZD5462 is an RXFP1 modulator that targets the relaxin receptor, which is part of the GPCR family. This compound exhibits anti-fibrotic and anti-inflammatory properties, making it a valuable tool for research into heart failure and related cardiovascular diseases. Its application in studies of RXFP1 signaling pathways can provide insights into potential therapeutic strategies for heart dysfunction. -
RXFP2 Agonist
RXFP2 Agonist 2 is a selective allosteric agonist of the RXFP2 receptor, exhibiting an EC50 of 0.38 μM. This compound promotes osteoblast mineralization and enhances bone formation in female mice. RXFP2 Agonist 2 is valuable for research studies focused on osteoporosis and bone health. -
RXFP3/4 Agonist
RXFP3/4 Agonist 2 is a potent nonpeptide dual agonist targeting RXFP3 and RXFP4, with EC50 values of 3.1 nM and 2.7 nM, respectively. This compound effectively promotes the interaction between RXFP3 and β-arrestin-2, displaying EC50 values ranging from 10 to 22 nM. RXFP3/4 Agonist 2 is valuable for investigating receptor signaling pathways and exploring potential therapeutic applications related to metabolic and cardiovascular diseases. -
RXFP4 Agonist
A13:B7-24-GG is a selective RXFP4 agonist that acts through its high-affinity binding (Ki = 2.29 nM) to the RXFP4 receptor, while demonstrating minimal interaction with RXFP3 (Ki = 602.56 nM). This compound effectively inhibits cAMP production with an EC50 of 1.17 nM and facilitates the recruitment of β-Arrestin2, showing an EC50 of 22.39 nM. A13:B7-24-GG is primarily utilized in research focused on chronic constipation and related gastrointestinal disorders. -
RXFP1 Agonist
AZ7976 is a highly selective agonist for the Relaxin Family Peptide Receptor 1 (RXFP1), displaying a pEC50 value greater than 10.5. This compound enhances cAMP signaling through an allosteric mechanism, resulting in a physiological increase in heart rate. AZ7976 is suitable for investigations in cardiovascular disease research and related studies focusing on RXFP1-mediated pathways. -
RXFP1 Receptor Agonist
RXFP1 receptor agonist-6 is a potent agonist of the RXFP1 receptor, effectively stimulating cAMP production in HEK293 cells that stably express the human RXFP1. With an EC50 value of 12 nM, this compound is valuable for research applications focused on understanding RXFP1 signaling pathways and their implications in various physiological processes. -
RXFP2 Agonist
RXFP2 Agonist 1 selectively targets the relaxin family peptide receptor 2 (RXFP2) and demonstrates potent agonistic activity with an EC50 of 0.06 µM. This compound plays a significant role in cellular signaling pathways associated with bone metabolism and has potential applications in osteoporosis research. Its ability to modulate RXFP2 activity makes it a valuable tool for studies focused on therapeutic strategies aimed at bone health and regeneration. -
RXFP1 Receptor Agonist
RXFP1 receptor agonist-10 is a potent RXFP1 receptor agonist with an EC50 value of 0.5 nM. This compound exhibits significant biological activity, making it a valuable tool for studying the physiological roles of the RXFP1 receptor. Its utility in research extends to investigations related to heart failure, providing insights into the potential therapeutic mechanisms involving RXFP1 modulation. -
RXFP1 Activator
Efadirelaxin alfa is a selective agonist of the relaxin/insulin-like family peptide receptor RXFP1, exhibiting a prolonged terminal half-life following subcutaneous administration. It demonstrates significant anti-cardiac hypertrophy and anti-fibrotic properties by modulating the TGF-β1/Smad2 and AKT/eNOS signaling pathways. Efadirelaxin alfa effectively reverses cardiac hypertrophy and collagen deposition while improving cardiac systolic function, all without affecting blood pressure or heart rate. This compound is primarily utilized in research focused on heart failure mechanisms and therapies. -
RXFP1 Receptor Agonist
RXFP1 receptor agonist-8 is a selective agonist for the RXFP1 receptor, which plays a crucial role in the modulation of cellular signaling pathways. This compound effectively stimulates cAMP production in HEK293 cells that stably express human RXFP1, exhibiting an EC50 value of 1.8 nM. It is valuable for research applications investigating RXFP1-mediated signaling and its physiological implications. -
RXFP3 Agonist
RXFP3 Agonist 1 is a nonpeptide compound that selectively activates the RXFP3 receptor with an EC50 value of 6937 nM. This reagent is valuable for investigating the physiological roles of RXFP3 in various biological processes, including mood regulation and reproductive functions. Its application extends to studies exploring potential therapeutic targets for diseases associated with RXFP3 signaling pathways. -
RXFP1 Receptor Agonist
RXFP1 receptor agonist-4 is a selective agonist for the RXFP1 receptor. It effectively stimulates cyclic AMP (cAMP) production in HEK293 cells that stably express the human RXFP1 receptor, demonstrating an EC50 value of 4.9 nM. This compound is valuable for research applications related to the RXFP1 signaling pathway and its role in various physiological processes. -
RXFP1 Receptor Agonist
RXFP1 receptor agonist-1 selectively targets the RXFP1 receptor, leading to the activation of downstream signaling pathways. This compound effectively stimulates cyclic AMP (cAMP) production in HEK293 cells that stably express human RXFP1, demonstrating an EC50 value of 300 nM. It serves as a valuable tool for research into receptor signaling mechanisms and the physiological implications of RXFP1 activation.
