Catalog No.
Product Name
Application
Product Information
Citations
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ICMT Inhibitor
UCM-1336 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 of 2 μM. This compound effectively induces mislocalization of endogenous Ras, resulting in decreased Ras activation. UCM-1336 has shown the ability to trigger cell death through autophagy and apoptosis, making it a valuable tool for research in cancer biology and signal transduction pathways. -
ICMT Inhibitor
POP-3MB is an inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 2.5 μM. It effectively alters the subcellular localization of K-Ras, leading to inhibition of Ras activation. Additionally, POP-3MB demonstrates the capacity to inhibit Erk phosphorylation, making it a valuable tool for research into Ras signaling pathways and related oncogenic processes. -
Icmt Inhibitor
Cysmethynil is an inhibitor of Isoprenylcysteine carboxylmethyltransferase (Icmt) with an IC50 of 2.4 μM. It disrupts RAS membrane binding and interferes with EGF signal transduction, leading to cell cycle arrest in the G1 phase and the induction of autophagy. Cysmethynil effectively inhibits the proliferation of PC3 prostate cancer cells and demonstrates synergistic effects with chemotherapeutic agents such as Paclitaxel and Doxorubicin. This compound is applicable for research into solid tumors, including prostate cancer. -
ICMT Inhibitor
ICMT-IN-1 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.0013 μM. This compound has been shown to effectively induce the accumulation of ICMT in the cytoplasm of HCT-116 cells. Additionally, ICMT-IN-1 exhibits significant antiproliferative activity against various cancer cell lines that express K-Ras and N-Ras, making it a valuable tool for research in cancer biology and therapeutic development. -
ICMT Inhibitor
ICMT-IN-30 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.27 μM. This compound is essential for studying the role of ICMT in various biological processes, including protein modification and signaling pathways. Its inhibition can be utilized in research focused on cancer, neurodegeneration, and other diseases associated with abnormal protein prenylation. -
ICMT Inhibitor
ICMT-IN-28 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 value of 0.008 μM. This compound effectively disrupts the ICMT-mediated methylation of isoprenylated proteins, playing a critical role in cellular signaling pathways. ICMT-IN-28 is utilized in studies investigating the regulation of protein function and has potential applications in cancer research and other areas of cell biology. -
ICMT Inhibitor
ICMT-IN-52 is a specific inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.052 μM. This compound plays a crucial role in research on post-translational modifications and protein maturation related to oncogenesis and cellular signaling. Its ability to effectively inhibit ICMT makes it a valuable tool for studying the biological implications of ICMT activity in various disease models. -
ICMT Inhibitor
ICMT-IN-5 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.3 μM. This compound modulates protein localization and activity through the inhibition of ICMT, making it valuable for studying signal transduction pathways and post-translational modifications. ICMT-IN-5 is suitable for research applications focused on cancer biology, neurobiology, and other fields where ICMT plays a critical role in regulating protein function. -
ICMT Inhibitor
ICMT-IN-34 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.17 μM. This compound exhibits significant biological activity in the modulation of protein methylation, influencing various cellular processes. It is valuable for research applications aimed at elucidating the roles of ICMT in signal transduction and cancer biology. -
ICMT Inhibitor
ICMT-IN-51 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.55 μM. This compound is essential for studying the role of ICMT in post-translational modifications of proteins, particularly in signaling pathways related to cancer and other diseases. Its utility in biochemical assays makes it a valuable tool for researchers investigating the therapeutic potential of ICMT modulation. -
ICMT Inhibitor
ICMT-IN-7 is a potent inhibitor of isoprenylcysteine methyltransferase (ICMT), with an IC50 of 0.015 μM. This compound effectively induces the accumulation of ICMT in the cytoplasm of HCT-116 cells and demonstrates significant inhibitory effects on the proliferation of various cancer cell lines that express K-Ras and N-Ras. ICMT-IN-7 is valuable for research applications targeting ICMT-related pathways in cancer biology. -
ICMT Inhibitor
ICMT-IN-6 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.09 μM. This compound effectively disrupts ICMT activity, which plays a critical role in protein prenylation processes. ICMT-IN-6 is valuable for studying the biological implications of ICMT inhibition and its potential therapeutic applications in cancer and other diseases involving dysregulated protein prenylation. -
ICMT Inhibitor
ICMT-IN-50 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), with an IC50 value of 0.31 μM. This compound is utilized in research to investigate the role of ICMT in post-translational modifications and its impact on protein function and signaling pathways. Suitable for studies involving cancer biology and therapeutic development, ICMT-IN-50 provides a valuable tool for understanding ICMT's biological significance. -
ICMT Inhibitor
ICMT-IN-24 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.19 μM. This compound is utilized in research to explore the role of ICMT in post-translational modifications and its implications in various cellular processes. Its ability to inhibit ICMT makes it a valuable tool for studying protein activity and signaling pathways related to cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-15 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.032 μM. By blocking the activity of ICMT, this compound disrupts post-translational modifications of proteins involved in signaling pathways. ICMT-IN-15 is utilized in research focused on understanding the role of protein methylation in cellular processes and disease mechanisms, making it a valuable tool for studies in cancer, neurobiology, and other fields. -
ICMT Inhibitor
ICMT-IN-13 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.47 μM. This compound is crucial for studying the role of ICMT in post-translational modifications of proteins, particularly in oncogenic signaling pathways. Its application in chemical biology can provide insights into the regulation of protein function and potential therapeutic strategies targeting cancer progression. -
ICMT Inhibitor
ICMT-IN-46 is an inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.556 μM. This compound plays a critical role in modulating protein prenylation processes, impacting various signaling pathways. It is suitable for research applications focused on cellular signaling, protein modification, and the investigation of diseases where ICMT activity is a key factor. -
ICMT Inhibitor
ICMT-IN-37 is a selective inhibitor of Isoprenylcysteine methyltransferase (ICMT), exhibiting an IC50 of 0.308 μM. This compound is instrumental for investigating the role of ICMT in various cellular processes, including protein localization and signaling pathways. Its application extends to studies on post-translational modifications and the functional implications of ICMT inhibition in cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-27 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 value of 0.1 μM. This compound effectively disrupts the post-translational modification of proteins that rely on ICMT activity. It is primarily utilized in studies involving protein regulation, signal transduction, and cancer research, enabling scientists to explore the role of ICMT in various biological processes. -
ICMT Inhibitor
ICMT-IN-20 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.682 μM. This compound is instrumental in the study of post-translational modifications in proteins, facilitating research into their role in various cellular processes. ICMT-IN-20 is applicable in investigations of signal transduction pathways and may contribute to the understanding of certain diseases where ICMT activity is disrupted. -
ICMT Inhibitor
ICMT-IN-44 is a selective inhibitor of isopeptidase cyseel methyltransferase (ICMT) with an IC50 value of 0.167 μM. This compound is designed to disrupt the methylation of cyseel proteins, thereby influencing post-translational modifications and cellular signaling pathways. ICMT-IN-44 is valuable in biochemical research for studying the role of ICMT in various physiological and pathological processes, making it a useful tool in drug discovery and development. -
ICMT Inhibitor
ICMT-IN-36 is a specific inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), showing an IC50 value of 0.181 μM. This compound is valuable for researchers investigating ICMT’s role in protein modification and its implications in cancer and other diseases. Its applications include studying protein stability and signaling pathways related to post-translational modifications. -
ICMT Inhibitor
ICMT-IN-12 is a selective inhibitor of isoprenylcysteine carboxymethyltransferase (ICMT) with an IC50 value of 0.42 μM. This compound demonstrates important biological activity by blocking ICMT-mediated post-translational modifications, which play a crucial role in protein function and stability. ICMT-IN-12 is applicable in studies focusing on signaling pathways and cellular processes influenced by protein prenylation, making it a valuable tool for research in cancer biology and therapeutic development. -
ICMT Inhibitor
ICMT-IN-8 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.652 μM. This compound is primarily utilized in research applications focusing on protein prenylation and related signaling pathways. Investigating ICMT's role can provide insights into its potential implications in cancer and other diseases linked to dysregulated protein modification. -
ICMT Inhibitor
ICMT-IN-21 is a potent inhibitor of isoprenylcysteine O-methyltransferase (ICMT), with an IC50 value of 8.8 μM. This compound features a sulfonamide-modified farnesyl cysteine structure, with key farnesyl and carboxylic acid motifs critical for its inhibitory activity. ICMT-IN-21 is valuable for investigating the role of ICMT in post-translational modifications and cellular signaling processes, providing insights into potential therapeutic interventions. -
ICMT Inhibitor
ICMT-IN-17 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) with an IC50 of 0.38 μM. This compound disrupts the methylation of isoprenylated proteins, which is crucial for their membrane localization and function. ICMT-IN-17 serves as a valuable tool in research aimed at understanding the role of protein methylation in various cellular processes and its implications in disease states. -
ICMT Inhibitor
ICMT-IN-26 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.36 μM. This compound is utilized in biochemical research to investigate the role of ICMT in protein modification and signal transduction pathways. Its inhibition profile makes it a valuable tool for studying diseases associated with dysregulated protein methylation. -
ICMT Inhibitor
ICMT-IN-16 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.131 μM. This compound is utilized in research to elucidate the role of ICMT in protein modification and signal transduction pathways. Its inhibition can provide insights into various cellular processes, making it a valuable tool for studies focused on cancer biology and other related fields. -
ICMT Inhibitor
ICMT-IN-41 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) with an IC50 of 0.069 μM. This compound has demonstrated significant potential in regulating post-translational modifications of proteins, making it valuable for studies related to cell signaling and protein stability. It is particularly relevant in research focused on cancer biology and the roles of protein modification in disease pathways. -
ICMT Inhibitor
ICMT-IN-31 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 value of 0.0038 μM. This compound effectively disrupts protein farnesylation, influencing cellular processes such as signal transduction and protein localization. ICMT-IN-31 is particularly valuable for research in cancer biology and the study of post-translational modifications. -
ICMT Inhibitor
ICMT-IN-54 is an adamantyl analogue that functions as an inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 value of 12.4 μM. This compound effectively inhibits the methylation of BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) in Saccharomyces cerevisiae expressing ICMT, thereby demonstrating its potential to interfere with ICMT-mediated methylation processes. ICMT-IN-54 is a valuable tool for research into the roles of ICMT in cellular signaling and protein modification. -
ICMT Inhibitor
ICMT-IN-18 is a potent inhibitor of isoprenylcysteine carboxymethyltransferase (ICMT), demonstrating an IC50 of 0.066 μM. This compound is valuable for investigating the role of ICMT in post-translational modifications and protein processing. Its applications extend to studies of cancer biology and signal transduction pathways where altered protein function may influence disease progression. -
ICMT Inhibitor
ICMT-IN-40 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.031 μM. This compound disrupts protein modification by inhibiting cysteine methylation, a critical process for the function and stability of various proteins involved in cellular signaling. ICMT-IN-40 is useful in research applications focused on studying protein prenylation and its implications in cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-11 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.031 μM. This compound is valuable for research into protein post-translational modifications and their implications in various cellular processes. It is particularly useful in studies focused on cancer biology and signaling pathways involving prenylated proteins. -
ICMT Inhibitor
ICMT-IN-29 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.019 μM. This compound exhibits significant inhibitory activity and can be utilized in research applications aimed at elucidating the role of ICMT in protein modification and cellular signaling pathways. Its ability to selectively inhibit ICMT makes it a valuable tool for studying the implications of isoprenylation in various biological contexts. -
ICMT Inhibitor
ICMT-IN-38 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.049 μM. This compound is valuable for investigating the role of ICMT in post-translational modifications and its implications in various biological processes. Research applications include studies on cancer biology and cellular signaling pathways, where modulation of ICMT activity may reveal novel therapeutic targets. -
ICMT Inhibitor
ICMT-IN-43 is a potent inhibitor of the isoprenylcysteine carboxyl methyltransferase (ICMT) enzyme, with an IC50 value of 0.04 μM. This compound is instrumental in studying the role of protein methylation in various cellular processes and signaling pathways. ICMT-IN-43 can be utilized in research focused on cancer biology, neurodegenerative diseases, and other pathologies linked to post-translational modifications. -
ICMT Inhibitor
ICMT-IN-39 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.031 μM. This compound effectively disrupts the methylation process of isoprenylated proteins, providing valuable insights into cellular signaling pathways. ICMT-IN-39 is applicable in research focused on the roles of protein modification in various diseases, including cancer and neurodegenerative disorders. -
ICMT Inhibitor
ICMT-IN-32 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), showcasing an IC50 value of 0.777 μM. This compound is utilized in biochemical research to examine the role of ICMT in post-translational modifications of proteins. Its inhibitory properties make it valuable for studying signaling pathways and cellular processes related to protein farnesylation. -
ICMT Inhibitor
ICMT-IN-23 is a selective inhibitor of Isoprenylcysteine carboxylmethyltransferase (ICMT), exhibiting an IC50 value of 0.123 μM. This compound plays a crucial role in studying post-translational modifications involved in protein function and stability. ICMT-IN-23 is valuable for research applications focusing on signal transduction, protein interaction studies, and the development of novel therapeutic strategies targeting ICMT. -
ICMT Inhibitor
ICMT-IN-10 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), with an IC50 value of 0.184 μM. This compound effectively disrupts the methylation of isoprenylated proteins, thereby playing a critical role in various signaling pathways. ICMT-IN-10 is valuable for studying the biological implications of ICMT in cancer research and potentially in other diseases associated with aberrant protein methylation. -
ICMT Inhibitor
ICMT-IN-25 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.025 μM. This compound is significant in biochemical research focused on post-translational modifications, particularly in the study of protein localization and function mediated by ICMT. Its application extends to the investigation of cancer biology and other diseases where ICMT plays a crucial role in regulating protein activity. -
ICMT Inhibitor
ICMT-IN-53 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.96 μM. This compound demonstrates significant antiproliferative activity, effectively inhibiting the growth of MDA-MB-231 and PC3 cancer cell lines with IC50 values of 5.14 μM and 5.88 μM, respectively. ICMT-IN-53's PAMPA permeability makes it suitable for various biological research applications, particularly in the study of cancer cell proliferation and signaling pathways. -
ICMT Inhibitor
ICMT-IN-48 is a competitive inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), with a Km of 13 μM for the prenylated methyl acceptor, the enzyme's initial substrate. This compound effectively inhibits ICMT activity, demonstrating IC50 values of 3.5 μM at 1×Km S-adenosylmethionine (SAM) and 2.3 μM at 10×Km SAM. ICMT-IN-48 is valuable for studying the role of ICMT in cellular signaling and post-translational regulation related to prenylated proteins in various biological systems. -
ICMT Inhibitor
ICMT-IN-45 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.132 μM. This compound disrupts the post-translational modification of proteins, thereby influencing signaling pathways associated with cancer and other diseases. ICMT-IN-45 is useful in research applications aimed at understanding ICMT-related biological processes and evaluating the potential therapeutic effects of ICMT inhibition. -
ICMT Inhibitor
ICMT-IN-2 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), demonstrating an IC50 value of 0.168 μM. This compound effectively disrupts protein prenylation processes, making it a valuable tool for investigating the role of ICMT in various biological systems. ICMT-IN-2 has applications in studying signal transduction pathways and potential therapeutic interventions in diseases associated with aberrant protein modifications. -
ICMT Inhibitor
ICMT-IN-14 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.025 μM. This compound plays a critical role in the modulation of post-translational modifications of proteins associated with oncogenic signaling pathways. ICMT-IN-14 is ideal for research applications focused on protein methylation dynamics and the investigation of cancer biology. -
ICMT Inhibitor
ICMT-IN-47 is a specific inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.76 μM. This compound effectively disrupts ICMT activity, which is critical in the post-translational modification of proteins involved in various signaling pathways. ICMT-IN-47 can be utilized in research applications focused on cancer biology, signaling mechanisms, and studies targeting prenylated proteins. -
ICMT Inhibitor
ICMT-IN-19 is a specific inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), demonstrating an IC50 value of 0.026 μM. This compound effectively blocks ICMT activity, impacting post-translational modifications of proteins that can influence various cellular processes. ICMT-IN-19 is suitable for research applications focusing on protein processing, signal transduction, and cancer biology. -
ICMT Inhibitor
ICMT-IN-22 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.63 μM. This compound is instrumental in research applications related to lipid modification pathways, playing a crucial role in understanding post-translational modifications of proteins. Its use can facilitate studies on cellular signaling, protein stability, and the implications of ICMT activity in various diseases.
