Catalog No.
Product Name
Application
Product Information
Citations
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RAAS antagonist
Candesartan is an angiotensin receptor blocker (also called an angiotensin-II receptor antagonist or an AIIRA).- Naomi Fukazawa, .et al. , Pharm Res, 2024, May;41(5):849-861 PMID: 38485855
- Hideki Kobara, .et al. , Molecular Medicine Reports, 2020, 22(2) PMID: 32626983
- Dao-Lai Zhang, .et al. , eLife, 2018, 7: e33432 PMID: 29393851
- Toshihide Kashihara, .et al. , J Physiol, 2017, Jul 1; 595(13): 4207-4225 PMID: 28295363
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AT1 antagonist
Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. -
Angiotensin II receptor antagonist
Tasosartan is an angiotensin II receptor antagonist. -
AT1 receptor antagonist
Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. -
AT1 Receptor Blocker
Azilsartan (TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension. -
angiotensin AT2 receptor antagonist
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.- Dao-Lai Zhang, .et al. , eLife, 2018, 7: e33432 PMID: 29393851
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angiotensin II receptor antagonist
BIBS39 is a nonpeptide angiotensin II (AII) receptor antagonists that displaced [125I] AII from its specific binding sites with a K(i) value of 29 +/- 7 nM for the AII subtype I (AT1) receptor and a K(i) value of 480 +/- 110 nM for the AII subtype 2 (AT2) receptor. -
angiotensin receptor-neprilysin inhibitor
LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. -
angiotensin II receptor type 1 antagonist
Azilsartan medoxomil is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. -
non-peptide angiotensin II receptor antagonist
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. - Tranilast is an inhibitor of the production of interleukin-6 in endothelial cells. It acts by reducing collagen synthesis in fibroblasts and inhibiting growth of neurofibroma cells.
- Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.
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angiotensin 1 (AT1) and AT2 receptor agonist
Angiotensin III is an angiotensin 1 (AT1) and AT2 receptor agonist. -
apelin agonist
Apelin agonist 1 is an oral selective apelin agonist AM-2995, a agonist of the APJ (APLNR, angiotensin receptor like-1) receptor, may be used in the treatment of cardiovascular conditions. -
angiotensin II receptor antagonist
Pratosartan is a selective angiotensin II receptor antagonist. -
AT1 receptor antagonist
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist. -
angiotensin II receptor type 1 antagonist
Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. -
angiotensin II and endothelin A receptor antagonist
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. -
angiotensin II receptor antagonist
Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist. -
angiotensin II type 1 receptor antagonist
Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist. -
AT2R antagonist
Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. -
angiotensin II receptor antagonist
EMD-66684 is a non-peptide angiotensin II receptor antagonist. - Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers.
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Angiotensin Receptor Inhibitor
YS-49 monohydrate is a selective angiotensin receptor inhibitor, primarily targeting the angiotensin II pathway. This compound effectively reduces angiotensin II-stimulated proliferation of vascular smooth muscle cells by inducing heme oxygenase-1, offering potential therapeutic insights for cardiovascular research. Additionally, as an isoquinoline alkaloid, YS-49 demonstrates significant positive inotropic effects through the activation of cardiac β-adrenoceptors, making it a valuable reagent for studies involving cardiac function and vascular biology. -
Angiotensin Receptor
CNP-38 is a C-type natriuretic peptide that primarily targets the angiotensin receptor. This compound exhibits potent biological activity associated with vasodilation and blood pressure regulation. CNP-38 is valuable in research applications related to cardiovascular physiology and potential therapeutic strategies for hypertension and heart failure. -
Angiotensin Receptor
Angiotensin II (5-8), human is a biologically active C-terminal fragment of the vasoconstrictor angiotensin II, targeting the angiotensin II type 1 (AT1) receptor. This fragment activates G protein-coupled receptors (GPCRs) in vascular smooth muscle cells, leading to increased intracellular calcium levels and vasoconstriction. Additionally, Angiotensin II (5-8) influences renal function by interacting with the Na+/H+ exchanger in the proximal tubules, making it a valuable tool for research in cardiovascular and renal physiology. -
Angiotensin Receptor Antagonist
Valsartan-d9 is a deuterated form of valsartan, an angiotensin II receptor antagonist. This compound is primarily used in research related to hypertension and heart failure, facilitating investigations into the mechanisms of blood pressure regulation and cardiovascular health. Its unique isotopic labeling allows for advanced tracking and analysis in pharmacokinetic and metabolic studies. -
Angiotensin Receptor Antagonist
Olmesartan lactone impurity is a cyclic ester derivative associated with Olmesartan, an angiotensin II receptor (AT1R) antagonist. This impurity can serve as a reference standard in analytical studies and quality control processes for assessing Olmesartan purity. Its relevance in hypertension research underscores its importance in understanding the pharmacological profiles of angiotensin receptor modulators. -
Angiotensin Receptor Activator
DuP-532 is an angiotensin type 1 receptor antagonist that plays a crucial role in the management of hypertension and heart failure. This compound is capable of reacting with various aryl and heteroaryl halides to yield perfluoroalkyl(hetero)arenes efficiently. Additionally, computational studies indicate that the introduction of a secondary phenyl ring ligand can decrease the energy barrier for the decarboxylation of perfluorocarboxylates, facilitating the perfluoroalkylation process. -
Angiotensin Receptor Inhibitor
H-Val-Pro-Pro-OH TFA is an inhibitor of Angiotensin I converting enzyme (ACE), demonstrating an IC50 of 9 μM. This milk-derived proline peptide derivative is utilized in research applications focused on cardiovascular biology and hypertension. Its role in modulating the renin-angiotensin system makes it a valuable tool for studying the effects of ACE inhibition in various physiological and pathological contexts. -
Angiotensin Receptor Antagonist
Dehydro Olmesartan is a potent angiotensin II receptor (AT1R) antagonist, derived from Olmesartan. This compound exhibits significant antihypertensive activity, making it valuable for research focused on hypertension and cardiovascular diseases. Its ability to inhibit AT1R provides insights into the mechanisms underlying blood pressure regulation and potential therapeutic strategies. -
Angiotensin Receptor Antagonist
Tetrahydro Aldosterone is an angiotensin receptor antagonist that effectively inhibits adrenal angiotensin II receptors, demonstrating an IC50 of 10 μM. This compound is utilized in research to investigate the role of the renin-angiotensin system in cardiovascular and renal physiology. Its application extends to exploring mechanisms of hypertension and related disorders. -
Angiotensin II Analogue
[Sar1, Ile8]-Angiotensin II is a synthetic analogue of angiotensin II that primarily targets angiotensin receptors, inducing various physiological effects. This peptide is known to elicit vasoconstriction in normal arterial tissue and promotes hypertrophic or hyperplastic responses in cultured vascular smooth muscle cells and diseased vasculature. Its versatile biological activity makes it valuable in research applications focused on cardiovascular physiology, vascular remodeling, and related pathophysiological processes. -
Angiotensin Receptor
ZD 7155 is a selective antagonist of the angiotensin II type 1 receptor (AT1R), known for its effects on renal function. Research indicates that ZD 7155 modulates electrolyte excretion, particularly increasing the excretion of sodium, potassium, and chloride in postnatal lamb models. In studies involving 6-week-old lambs, pretreatment with ZD 7155 significantly enhanced urine flow rates and free water clearance, while also reducing urine osmolality. This compound is essential for investigating the role of AT1R in renal physiology and the interactions with nitric oxide in electrolyte regulation. -
Angiotensin Receptor Antagonist
Olmesartan medoxomil impurity C is a chemical impurity related to Olmesartan medoxomil, a selective antagonist of the angiotensin AT1 receptor. It exhibits inhibitory activity with an IC50 value of 66.2 μM, making it relevant for studies focused on hypertension and cardiovascular disorders. This impurity can serve as a reference standard in the characterization and analytical assessment of Olmesartan medoxomil formulations in research applications. -
Angiotensin Receptor Activator
Mitolactol, an angiotensin receptor activator, exhibits effective inhibition of angiotensin-converting enzyme (ACE) with an IC50 value of 1.4 × 10 M. This compound is known for its ability to suppress the pressor response to angiotensin I when administered intravenously at a dose of 0.3 mg/kg in rat models. Mitolactol is of interest for research focusing on cardiovascular physiology, hypertension, and related therapeutic applications. -
Angiotensin II Analog
Nva-VYIHPF is an analog of Angiotensin II that selectively targets the angiotensin receptor type 1 (AT1). This compound exhibits potent binding affinity and biological activity, making it valuable for studying the renin-angiotensin system. Researchers can utilize Nva-VYIHPF in various applications, including cardiovascular research, hypertension studies, and investigations into cellular signaling pathways influenced by angiotensin II. -
Angiotensin Receptor
[Tyr(P)4] Angiotensin II is a phosphopeptide analog of angiotensin II that primarily targets the angiotensin receptor. It is known to induce vasoconstriction in normal arterial smooth muscle and promote cellular hypertrophy or hyperplasia in cultured cells and diseased vascular tissues. This compound is valuable for research into cardiovascular physiology, hypertension, and related pathologies. -
Angiotensin Receptor Agonist
Angiotensin II (1-4), human is an endogenous peptide that functions as an agonist for the angiotensin receptor. It primarily binds to the AT II type 1 (AT1) receptor, activating GPCRs in vascular smooth muscle cells, which leads to an increase in intracellular calcium levels. Additionally, Angiotensin II (1-4) influences the sodium/hydrogen exchanger in the proximal tubules of the kidney, playing a critical role in regulating blood pressure and fluid balance. This peptide is valuable for research applications related to cardiovascular function and renal physiology.
