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CCK

Cholecystokinin receptors (CCKRs) are a class of G-protein coupled receptors that respond to the peptide hormone cholecystokinin (CCK). CCK is predominantly found in the gastrointestinal tract and the central nervous system. There are two primary subtypes of cholecystokinin receptors: CCK-A (CCK1) receptor, mainly located in the pancreas, gallbladder, stomach, and certain areas of the brain, and CCK-B (CCK2) receptor, found predominantly in the brain and the stomach lining.

The primary function of CCKRs is to mediate the physiological actions of CCK. In the digestive system, CCK is involved in stimulating the digestion of fats and protein. It achieves this by inducing the secretion of digestive enzymes from the pancreas and bile from the gallbladder. Moreover, CCK plays a crucial role in regulating appetite by promoting satiety, making it a point of interest in obesity research.

In the central nervous system, CCK is involved in various functions, including anxiety, pain, and neuroendocrine control. CCK and its receptors are also implicated in psychiatric disorders like anxiety and panic attacks.

CCKRs are also significant in the medical field as potential targets for therapeutic intervention. For instance, CCK-B antagonists are being explored for their potential in treating anxiety disorders and gastrointestinal issues.

Overall, cholecystokinin receptors are integral to various physiological processes, from digestion to brain function, highlighting their importance in both understanding bodily functions and developing medical treatments.

Catalog No.

Product Name

Application

Product Information

Citations

A21396

GI 181771

cholecystokinin 1 receptor agonist

GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.

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A18541

Dexloxiglumide

CCKA receptor antagonist

Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8).

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A95686

Cionin

Peptide

Cionin is a disulfotyrosyl hybrid peptide derived from cholecystokinin and gastrin. It primarily targets cholecystokinin receptors, mediating various physiological functions such as gastric motility and enzyme secretion. This compound is utilized in research applications examining gastrointestinal physiology and the endocrine system. Its unique structure allows for the exploration of receptor interactions and signaling pathways in peptide studies.

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B19167

GW-5823

CCK-AR Agonist

GW-5823 is a selective agonist of the cholecystokinin A receptor (CCK-AR), exhibiting an EC50 of 70 nM. This compound plays a crucial role in modulating appetite and satiety signals, making it valuable for research focused on obesity and metabolic disorders. Its specificity allows for detailed investigations into CCK-AR-related pathways and therapeutic potentials in weight management.

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