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CCK

Cholecystokinin receptors (CCKRs) are a class of G-protein coupled receptors that respond to the peptide hormone cholecystokinin (CCK). CCK is predominantly found in the gastrointestinal tract and the central nervous system. There are two primary subtypes of cholecystokinin receptors: CCK-A (CCK1) receptor, mainly located in the pancreas, gallbladder, stomach, and certain areas of the brain, and CCK-B (CCK2) receptor, found predominantly in the brain and the stomach lining.

The primary function of CCKRs is to mediate the physiological actions of CCK. In the digestive system, CCK is involved in stimulating the digestion of fats and protein. It achieves this by inducing the secretion of digestive enzymes from the pancreas and bile from the gallbladder. Moreover, CCK plays a crucial role in regulating appetite by promoting satiety, making it a point of interest in obesity research.

In the central nervous system, CCK is involved in various functions, including anxiety, pain, and neuroendocrine control. CCK and its receptors are also implicated in psychiatric disorders like anxiety and panic attacks.

CCKRs are also significant in the medical field as potential targets for therapeutic intervention. For instance, CCK-B antagonists are being explored for their potential in treating anxiety disorders and gastrointestinal issues.

Overall, cholecystokinin receptors are integral to various physiological processes, from digestion to brain function, highlighting their importance in both understanding bodily functions and developing medical treatments.

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  1. A66234
    Cholecystokinin-J

    Cholecystokinin

    Cholecystokinin-J is a cholecystokinin peptide that primarily targets the cholecystokinin receptor. It is known to stimulate Ca2+ release, playing a significant role in various physiological processes such as digestion and satiety. This reagent is valuable for research applications in gastrointestinal physiology and neurobiology, facilitating studies on CCK-related pathways and functions.
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  2. A72749
    Enterostatin (rat)

    Activation Peptide

    Enterostatin (rat) is an activation peptide of procolipase that plays a significant role in modulating fat intake. This peptide selectively reduces body fat consumption and lowers serum cholesterol levels through a cholecystokinin 1 (CCK1) receptor-dependent mechanism. It serves as a valuable tool for research on energy balance, appetite regulation, and metabolic disorders.
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  3. A95686
    Cionin

    Peptide

    Cionin is a disulfotyrosyl hybrid peptide derived from cholecystokinin and gastrin. It primarily targets cholecystokinin receptors, mediating various physiological functions such as gastric motility and enzyme secretion. This compound is utilized in research applications examining gastrointestinal physiology and the endocrine system. Its unique structure allows for the exploration of receptor interactions and signaling pathways in peptide studies.
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  4. B19167
    GW-5823

    CCK-AR Agonist

    GW-5823 is a selective agonist of the cholecystokinin A receptor (CCK-AR), exhibiting an EC50 of 70 nM. This compound plays a crucial role in modulating appetite and satiety signals, making it valuable for research focused on obesity and metabolic disorders. Its specificity allows for detailed investigations into CCK-AR-related pathways and therapeutic potentials in weight management.
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