CCK

Cat. No.

A11769

CAS No.

107097-80-3

Loxiglumide (CR1505)

Synonyms: anoicacid; CR1505

Loxiglumide (CR1505) is a cholecystokinin antagonist

Cat. No.

A13671

CAS No.

343326-69-2

Z-360 calcium salt (Nastorazepide calcium salt)

Synonyms: Z360

Z-360 is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity.

Cat. No.

A13713

CAS No.

99247-33-3

Proglumide sodium salt

Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. It inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini.

Cat. No.

A15984

CAS No.

209219-38-5

Nastorazepide (Z-360)

Synonyms: Z360

Nastorazepide is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity.

Cat. No.

A18171

CAS No.

6620-60-6

Proglumide

Synonyms: W 5219; CR 242

Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. IProglumide is a known cholecystokinin (CCK) antagonist.

Cat. No.

A18288

CAS No.

25126-32-3

Sincalide

Synonyms: CCK-8; CCK-8S; Kinevac

Sincalide, also known as CCK-8, is a drug used to treat cholecystitis. Sincalide is an octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.

Cat. No.

A18367

CAS No.

17650-98-5

Ceruletide

Synonyms: Caerulein; Cerulein; FI-6934

Ceruletide is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.

Cat. No.

A18411

CAS No.

1452145-13-9

CCK2R Ligand-Linker Conjugates 1

CCK2R Ligand-Linker Conjugates 1 is a ligand-linker conjugate, which conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) via a hydrophilic peptide linker.

Cat. No.

A18541

CAS No.

119817-90-2

Dexloxiglumide

Synonyms: CR-2017

Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8).

Cat. No.

A21391

CAS No.

221671-61-0

SR 146131

SR 146131 is a potent, orally available, and selective nonpeptide (cholecystokinin 1) receptor agonist.

Cat. No.

A21396

CAS No.

305366-98-7

GI 181771

GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity.

Cat. No.

A22020

CAS No.

155488-25-8

Sograzepide

Synonyms: Netazepide; YF 476; YM-220

Sograzepide (Netazepide; YF 476; YM-220) is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC50 of 502 nM.

Cat. No.

A22047

CAS No.

10047-33-3

Gastrin I, human

Gastrin I, human is the endogenous peptide produced in the stomach, and increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor.

Cat. No.

A22716

CAS No.

39024-57-2

[Leu15]-Gastrin I (human)

[Leu15]-Gastrin I (human) is a peptide. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR).

Cat. No.

A22807

CAS No.

25679-24-7

Cholecystokinin Octapeptide, desulfated

Synonyms: CCK Octapeptide; desulfated

Cholecystokinin Octapeptide, desulfated is a synthetic desulfated octapeptides of cholecystokinin (CCK).

Cat. No.

A22817

CAS No.

1947-37-1

Tetragastrin

Synonyms: Cholecystokinin tetrapeptide; CCK-4

Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. Tetragastrin can stimulate gastric secretion. Tetragastrin is a Cholecystokinin (CCK-4) receptor agonist. Gastric mucosal protection.

Cat. No.

A23456

CAS No.

89911-69-3

N-acetyl CCK-(26-30) amide

Synonyms: CCK-(26-30) (sulfated)

N-acetyl CCK-(26-30) amide (CCK-(26-30) (sulfated)) is a cholecystokinin (CCK) receptor antagonist.

Cat. No.

A23473

CAS No.

89911-64-8

CCK (26-31) (non-sulfated)

CCK (26-31) (non-sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety. CCK (26-31) is also less active in non-sulfated than in sulfated form.

Cat. No.

A25929

CAS No.

70706-98-8

Sincalide ammonium

Synonyms: Cholecystokinin octapeptide ammonium; CCK-8 ammonium; SQ19844 ammonium

Sincalide ammonium is an amino acid polypeptide hormone analogue of cholecystokinin (CCK) that primarily targets gallbladder function. It is utilized in clinical settings for its ability to promote gallbladder contraction, thus facilitating the diagnosis of gallbladder and pancreatic disorders. By increasing bile secretion and causing the contraction of the gallbladder while relaxing the sphincter of Oddi, Sincalide ammonium aids in the efficient drainage of bile into the duodenum, making it a valuable tool in postevacuation cholecystography.

Cat. No.

A48960

CAS No.

558638-15-6

Antibacterial agent 241

Antibacterial agent 241 is a histidine kinase (HK) inhibitor with IC50 values of 14 μM for CckA and 238 μM for PhoQ. It demonstrates moderate antibacterial activity against various bacterial strains, including E. coli DC2, Bacillus cereus, and Bacillus subtilis, with minimum inhibitory concentration (MIC) values ranging from 12 to 74 μg/mL. This compound is suitable for research applications targeting bacterial signaling pathways and antibiotic resistance mechanisms.

Cat. No.

A49076

CAS No.

1801749-44-9

Ceclazepide

Synonyms: TR2-A

Ceclazepide is a cholecystokinin-2 receptor (CCK2R) antagonist that serves as an orally active inhibitor of Mycobacterium abscessus. This compound effectively reduces acid secretion in rat models and demonstrates significant suppression of both wild-type and multiple subspecies of M. abscessus. Importantly, Ceclazepide inhibits the growth of M. abscessus within macrophages while maintaining cell integrity, making it a valuable tool for research into mycobacterial infections and related therapeutic strategies.

Cat. No.

A59520

CAS No.

145084-28-2

YM022

YM022 is a highly potent and selective antagonist of the gastrin/cholecystokinin (CCK)-B receptor (CCK-BR). With Ki values of 68 pM for CCK-B and 63 nM for CCK-A, YM022 effectively blocks gastrin-induced gastric acid secretion and inhibits histidine decarboxylase activation in vivo. This compound is valuable for research applications related to gastrointestinal disorders and receptor signaling pathways.

Cat. No.

A59640

CAS No.

2923120-30-1

CCKBR agonist-1

CCKBR agonist-1 is a potent agonist of the cholecystokinin B receptor (CCKBR), preferentially activating Gq-proteins with an EC50 of 35 pM. This compound enhances neuronal survival, demonstrated by an EC50 of 37 pM, and has shown efficacy in mitigating cognitive decline in murine models. Mechanistically, CCKBR agonist-1 upregulates α-secretase (ADAM10) and the calcium signaling molecule PLCB4, leading to decreased amyloid β (Aβ) plaque formation and enhancement of long-term potentiation (LTP). CCKBR agonist-1 serves as a valuable tool for research into Alzheimer's disease.

Cat. No.

A59641

CAS No.

923714-61-8

CCKBR agonist-2

CCKBR agonist-2 is a selective agonist for the cholecystokinin B receptor (CCKBR), primarily activating the Gi signaling pathway with an EC50 of 0.27 nM. This compound demonstrates minimal interaction with Gq and Gs pathways, making it a valuable tool for studying Gi-mediated cellular responses. Despite its potency in activating CCKBR-Gi signaling, CCKBR agonist-2 does not exhibit significant neuroprotective effects in mouse models of Alzheimer's disease, highlighting the complexity of cognitive function modulation. This reagent is useful in research exploring the roles of CCKBR signaling in various physiological and pathological contexts.

Cat. No.

A59642

CAS No.

103420-77-5

Devazepide

Synonyms: L-364,718; MK-329

Devazepide is a potent, competitive, and selective antagonist of the cholecystokinin (CCK) receptor. It exhibits high affinity with IC50 values of 81 pM, 45 pM, and 245 nM for rat pancreatic, bovine gallbladder, and guinea pig brain CCK receptors, respectively. This nonpeptide agent is primarily utilized in research focused on gastrointestinal disorders, providing insights into gastrointestinal physiology and the therapeutic potential of CCK receptor modulation.