9-Decyn-1-ol serves as an alkyl/ether-based linker in the synthesis of PROTACs, facilitating the conjugation of various compounds. It is central to the generation of INY-03-041 by linking GDC-0068 and Lenalidomide, resulting in a potent pan-Akt degrader that selectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Additionally, 9-Decyn-1-ol features an alkyne group suitable for click chemistry applications, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, which is invaluable in chemical biology research.
9-Decyn-1-ol serves as an alkyl/ether-based linker in the synthesis of PROTACs, facilitating the conjugation of various compounds. It is central to the generation of INY-03-041 by linking GDC-0068 and Lenalidomide, resulting in a potent pan-Akt degrader that selectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Additionally, 9-Decyn-1-ol features an alkyne group suitable for click chemistry applications, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, which is invaluable in chemical biology research.
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