Fig. 1 · Structure
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9-Decyn-1-ol
PROTAC Linker
9-Decyn-1-ol serves as an alkyl/ether-based linker in the synthesis of PROTACs, facilitating the conjugation of various compounds. It is central to the generation of INY-03-041 by linking GDC-0068 and Lenalidomide, resulting in a potent pan-Akt degrader that selectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Additionally, 9-Decyn-1-ol features an alkyne group suitable for click chemistry applications, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, which is invaluable in chemical biology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 17643-36-6 |
| Applications | PROTAC Linker |
| Formula | C10H18O |
| Molecular Weight | 154.25 |
| SMILES | C#CCCCCCCCCO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.