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A 62176 hydrochloride

Name: A 62176 hydrochloride
Brand: Adooq Bioscience
SKU: A73241
Availability: OutOfStock

Cat. No. A73241 CAS 111783-54-1

Endogenous Metabolite

A 62176 hydrochloride is a potent inhibitor of DNA topoisomerase II, demonstrating significant activity in disrupting purine synthesis in cancer cells. By interacting with G-quadruplex structures, A 62176 hydrochloride reduces c-MYC mRNA expression and displaces nucleosomes from the non-template strand of rDNA. This mechanism leads to DNA damage that necessitates repair via BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways, highlighting its potential applications in cancer research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	111783-54-1
Applications	Endogenous Metabolite
Formula	C₂₀H₁₇ClFN₃O₄
Molecular Weight	417.82
SMILES	O=C(C1=CN2C3=C(OC4=C2C(C1=O)=CC(F)=C4N5CCC(C5)N)C=CC=C3)O.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.