α,β-Methylene-ATP dilithium is a selective agonist for P2X1 and P2X3 receptors, capable of crossing the blood-brain barrier. It induces a reflex pressor response by activating these receptors in peripheral muscles and the central locus coeruleus, with effects that can be inhibited by the P2X antagonist PPADS. Additionally, it stimulates noradrenergic neurons in the central locus coeruleus, contributing to antinociceptive effects that can be reduced by DSP-4. This compound is valuable for investigating the mechanisms underlying neuropathic pain, cardiovascular reflex regulation, and central nervous system analgesia.
α,β-Methylene-ATP dilithium is a selective agonist for P2X1 and P2X3 receptors, capable of crossing the blood-brain barrier. It induces a reflex pressor response by activating these receptors in peripheral muscles and the central locus coeruleus, with effects that can be inhibited by the P2X antagonist PPADS. Additionally, it stimulates noradrenergic neurons in the central locus coeruleus, contributing to antinociceptive effects that can be reduced by DSP-4. This compound is valuable for investigating the mechanisms underlying neuropathic pain, cardiovascular reflex regulation, and central nervous system analgesia.
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