Ac4-5SGlcNAc is a pro-inhibitor targeting carbohydrate-based glycosyltransferases, particularly OGTs. This compound effectively inhibits O-GlcNAc acylation, resulting in the modulation of neural induction processes in human embryonic stem cells and a reduction in the invasive characteristics of breast cancer cells. Additionally, Ac4-5SGlcNAc demonstrates broader activity against various carbohydrate-processing enzymes, making it a valuable tool for biochemical assays in glycosylation research.
Ac4-5SGlcNAc is a pro-inhibitor targeting carbohydrate-based glycosyltransferases, particularly OGTs. This compound effectively inhibits O-GlcNAc acylation, resulting in the modulation of neural induction processes in human embryonic stem cells and a reduction in the invasive characteristics of breast cancer cells. Additionally, Ac4-5SGlcNAc demonstrates broader activity against various carbohydrate-processing enzymes, making it a valuable tool for biochemical assays in glycosylation research.
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