Acadesine (Aicar,NSC 105823)

Catalog No.: A10028

AMPK activator

Acadesine (Aicar,NSC 105823)

Acadesine (Aicar,NSC 105823) Chemical Structure

CAS NO. 2627-69-2

Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • R. Lim, .et al. Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators., Placenta, 2015, Apr;36(4):454-62 PMID: 25659498
  • Stella Liong, .et al. Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women., J Physiol Biochem, 2015, Dec;71(4):703-17 PMID: 26407807

Biological Activity

Acadesine is a selective activator of AMPK in both hepatocytes and adipocytes.

Targets
AMPK (Cell-free assay) AMPKK (Cell-free assay)
In vitro (25°C) DMSO 44 mg/mL (170.38 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.73 mL 193.65 mL 387.3 mL
0.5 mM 7.75 mL 38.73 mL 77.46 mL
1 mM 3.87 mL 19.36 mL 38.73 mL
5 mM 0.77 mL 3.87 mL 7.75 mL

*The above data is based on the productmolecular weight 258.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10028
Actions Activator
CAS No. 2627-69-2
Formula C9H14N4O5
M. Wt 258.2
Purity >98%
Synonyms AICAR, AICA-riboside, NSC-105823, NSC105823
SMILES C1=NC(=C(N1[[email protected]]2[[email protected]@H]([[email protected]@H]([[email protected]](O2)CO)O)O)N)C(=O)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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