Actinobolin hemisulfate is an antibiotic that primarily inhibits protein synthesis by targeting both bacterial and eukaryotic ribosomes. This compound demonstrates significant antibacterial activity against Mycobacterium smegmatis and Escherichia coli, with IC50 values of 19.2 μmol/L and 27.9 μmol/L, respectively. Additionally, it acts on rabbit reticulocyte lysate with an IC50 of 288 μmol/L. Actinobolin hemisulfate is valuable for research applications focusing on bacterial resistance and protein synthesis inhibition mechanisms.
Actinobolin hemisulfate is an antibiotic that primarily inhibits protein synthesis by targeting both bacterial and eukaryotic ribosomes. This compound demonstrates significant antibacterial activity against Mycobacterium smegmatis and Escherichia coli, with IC50 values of 19.2 μmol/L and 27.9 μmol/L, respectively. Additionally, it acts on rabbit reticulocyte lysate with an IC50 of 288 μmol/L. Actinobolin hemisulfate is valuable for research applications focusing on bacterial resistance and protein synthesis inhibition mechanisms.
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