ACY-738

Catalog No.: A15934

HDAC6 inhibitor

ACY-738

ACY-738 Chemical Structure

CAS NO. 1375465-91-0

ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$180.00
25 mg
$400.00
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  • Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48

Biological Activity

ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.
In vitro DMSO 46 mg/mL (170.18 mM)
Water Insoluble
Ethanol 1 mg/mL (3.69 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37 mL 184.99 mL 369.97 mL
0.5 mM 7.4 mL 37 mL 73.99 mL
1 mM 3.7 mL 18.5 mL 37 mL
5 mM 0.74 mL 3.7 mL 7.4 mL

*The above data is based on the productmolecular weight 270.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15934
Actions Inhibitor
CAS No. 1375465-91-0
Formula C14H14N4O2
M. Wt 270.29
Solubility DMSO
Purity >98%
Synonyms ACY 738, ACY738
SMILES O=C(C1=CN=C(NC2(C3=CC=CC=C3)CC2)N=C1)NO
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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