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Adenophostin A

IP3 Receptor Modulator

Adenophostin A is a potent modulator of inositol 1,4,5-trisphosphate receptors (IP3) that functions as a calcium (Ca2+) releaser, exhibiting an IC50 of 1.3 nM and an EC50 of 1.4 nM in rat models. This compound effectively stimulates Ca2+ release from intracellular stores and microsomes, inhibits the binding of [3H]IP3 to plasma membrane receptors, and activates chloride channels. Notably, Adenophostin A is resistant to phosphorylation and dephosphorylation by metabolic enzymes, thereby sustaining its activity and enhancing cytoplasmic Ca2+ levels in vascular smooth muscle cells. This reagent is highly relevant for research on hemorrhagic shock and related physiological studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	149091-92-9
Applications	IP3 Receptor Modulator
Formula	C₁₆H₂₆N₅O₁₈P₃
Molecular Weight	669.32
SMILES	O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O[C@@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)OP(O)(O)=O)OP(O)(O)=O)O)CO

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.