AF-353 hydrochloride is a potent and selective antagonist of the P2X3 and P2X2/3 receptors, exhibiting a pIC50 of 8.0 for both human and rat P2X3 and a pIC50 of 7.3 for human P2X2/3. This compound is notable for its oral bioavailability, making it suitable for in vivo studies. AF-353 hydrochloride is primarily utilized in research applications focused on pain modulation and the study of purinergic signaling pathways.
AF-353 hydrochloride is a potent and selective antagonist of the P2X3 and P2X2/3 receptors, exhibiting a pIC50 of 8.0 for both human and rat P2X3 and a pIC50 of 7.3 for human P2X2/3. This compound is notable for its oral bioavailability, making it suitable for in vivo studies. AF-353 hydrochloride is primarily utilized in research applications focused on pain modulation and the study of purinergic signaling pathways.
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